Is green tea good for HIV-1 infection?

Among the properties ascribed to EGCG are anti-tumorigenic, anti-inflammatory, antioxidative, antiproliferative, antibacterial, and antiviral effects.8,10,12 Epidemiologic and preclinical studies have shown that drinking green tea is associated with a lower incidence of human cancer.8,15 This protec...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2003-11, Vol.112 (5), p.851-853
Main Authors: Nance, Christina L, Shearer, William T
Format: Article
Language:English
Subjects:
Antiviral Agents - pharmacology
Catechin - analogs & derivatives
Catechin - pharmacology
catechins
CD4 HIV-1 binding domain
CD4 molecule
CD4 pocket for EGCG
competitive inhibition
conformational fit
electron density map
Green tea
HIV
HIV Infections - drug therapy
HIV-1 - drug effects
Human immunodeficiency virus
Humans
Immune system
Medical research
Phytotherapy
Plant Preparations - therapeutic use
protein databank
Space life sciences
Studies
Tea
Tea - chemistry
Viral infections
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Summary:Among the properties ascribed to EGCG are anti-tumorigenic, anti-inflammatory, antioxidative, antiproliferative, antibacterial, and antiviral effects.8,10,12 Epidemiologic and preclinical studies have shown that drinking green tea is associated with a lower incidence of human cancer.8,15 This protective effect of green tea has been observed in pancreatic, colon, rectal, skin, breast, prostate, liver, and lung cancer.8,15 The major component of green tea, EGCG, has been shown to have tumor antimetastatic and antiangiogenic activities, as has been observed in its inhibition of adhesion of carcinoma cells16 and significant prevention of growth of new blood vessels.17 EGCG is thought to be the most potent chemopreventive component of the catechins, inasmuch as it possesses both pyrogallol and galloyl moieties13 (Fig 1). Because of the inherent flexibility of the EGCG molecule (due to the 4 key dihedral angles essentially covering the entire 360-degree range of rotational freedom) and the size of the molecule,21 there is a wide range of possible conformations for docking into the region flanked by Phe 43 and Arg 59.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2003.08.048