Aberrant expression of T-plastin in Sezary cells

Mycosis fungoides (MF) and its leukemic variant, Sezary syndrome (SS), are the most common cutaneous T-cell lymphomas, with a combined incidence of 0.36 of 100,000 person-years. Although thought to be closely related to mature T-helper cells, the true nature of the cancer cells in MF/SS is unknown....

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2003-11, Vol.63 (21), p.7122-7127
Main Authors: SU, Ming-Wan, DOROCICZ, Irene, DRAGOWSKA, Wieslawa H, HO, Vincent, GANG LI, VOSS, Nicolas, GASCOYNE, Randy, YOUWEN ZHOU
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antineoplastic agents
Biological and medical sciences
Biomarkers, Tumor - biosynthesis
Biomarkers, Tumor - genetics
Female
Humans
Male
Medical sciences
Membrane Glycoproteins
Microfilament Proteins
Middle Aged
Pharmacology. Drug treatments
Phosphoproteins - biosynthesis
Phosphoproteins - genetics
Protein Isoforms
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Sezary Syndrome - blood
Sezary Syndrome - genetics
Sezary Syndrome - metabolism
Sezary Syndrome - pathology
T-Lymphocytes, Helper-Inducer - metabolism
T-Lymphocytes, Helper-Inducer - physiology
Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mycosis fungoides (MF) and its leukemic variant, Sezary syndrome (SS), are the most common cutaneous T-cell lymphomas, with a combined incidence of 0.36 of 100,000 person-years. Although thought to be closely related to mature T-helper cells, the true nature of the cancer cells in MF/SS is unknown. In addition, there is no known specific marker for MF/SS cancer cells, which can result in difficulties in the diagnosis and treatment. To identify MF/SS-specific markers, Sezary cancer cells were analyzed with a global genomic screening tool, the modified representational difference analysis. It was discovered that unlike T-helper cells from healthy individuals or patients with nonmalignant dermatoses, Sezary cells from most patients with Sezary syndrome aberrantly expressed T-plastin mRNA and protein. This is the first time T-plastin protein, a cytoplasmic protein regulating actin assembly and cellular motility, has been detected in the hematopoietic cells. Therefore, T-plastin has the potential to be a Sezary cell-specific marker valuable for diagnostic and treatment of Sezary syndrome.
ISSN:0008-5472
1538-7445