BMD at Multiple Sites and Risk of Fracture of Multiple Types: Long‐Term Results From the Study of Osteoporotic Fractures

In a large cohort of U.S. women aged 65 and older, we report the relationships of BMD measured at several sites, and subsequent fracture risk at multiple sites over >8 years of follow‐up. Although we found almost all fracture types to be related to low BMD, the overall proportion of fractures att...

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Bibliographic Details
Published in:Journal of bone and mineral research 2003-11, Vol.18 (11), p.1947-1954
Main Authors: Stone, Katie L, Seeley, Dana G, Lui, Li‐Yung, Cauley, Jane A, Ensrud, Kristine, Browner, Warren S, Nevitt, Michael C, Cummings, Steven R
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Bone and Bones - pathology
Bone and Bones - physiology
Bone Density
bone mineral density
Disease Susceptibility
Diseases of the osteoarticular system
Female
Follow-Up Studies
fracture
Fractures, Bone - complications
Fractures, Bone - epidemiology
Fractures, Bone - physiopathology
Fractures, Bone - prevention & control
Humans
Incidence
Injuries of the limb. Injuries of the spine
Medical sciences
osteoporosis
Osteoporosis - complications
Osteoporosis - physiopathology
Osteoporosis. Osteomalacia. Paget disease
population attributable risk
Proportional Hazards Models
Risk Factors
Traumas. Diseases due to physical agents
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Summary:In a large cohort of U.S. women aged 65 and older, we report the relationships of BMD measured at several sites, and subsequent fracture risk at multiple sites over >8 years of follow‐up. Although we found almost all fracture types to be related to low BMD, the overall proportion of fractures attributable to low BMD is modest. Introduction: Although several studies have reported the relationship between bone mineral density (BMD) and subsequent fracture risk, most have been limited by short follow‐up time, BMD measures at only one or two sites, or availability of data for only select fracture types. Materials and Methods: In the multicenter Study of Osteoporotic Fractures (SOF), we studied the relationship of several different BMD measures to fracture risk of multiple types in 9704 non‐black women aged 65 and older. We previously reported on the relationship of peripheral BMD measures to risk of several types of fracture during an average 2.2‐year follow‐up period. In this expanded analysis, we present results of the relationship of both peripheral and central BMD measures and fractures of multiple types during 10.4 and 8.5 years of follow‐up, respectively. We also report population attributable risk (PAR) estimates for osteoporosis and risk of several types of fracture. Results: Our results show that almost all types of fractures have an increased incidence in women with low BMD. However, hip BMD is somewhat more strongly related to most of the fracture types studied than spine or peripheral BMD measures. Nonetheless, the proportion of fractures attributable to osteoporosis (based on a standard definition of osteoporosis) is modest, ranging from
ISSN:0884-0431
1523-4681
DOI:10.1359/jbmr.2003.18.11.1947