Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center

Staphylococcus aureus strain HMC3 isolated at the Hershey Medical Center, was resistant to vancomycin (VRSA) through the presence of the vanA resistance gene; it also contained mecA, erm(A), erm(B), tet(K) and aac(6′)-aph(2″), conferring resistance to licensed β-lactams, macrolides, tetracycline and...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2003-11, Vol.52 (5), p.864-868
Main Authors: Bozdogan, Bülent, Esel, Duygu, Whitener, Cynthia, Browne, Frederick A., Appelbaum, Peter C.
Format: Article
Language:English
Subjects:
Aged
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
antimicrobial susceptibilities
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biological and medical sciences
Drug Resistance, Multiple, Bacterial
Humans
Male
mechanisms of resistance
Medical sciences
Microbial Sensitivity Tests
Pennsylvania
Pharmacology. Drug treatments
S. aureus
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - drug effects
Vancomycin - pharmacology
Vancomycin Resistance - genetics
VRSA
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Staphylococcus aureus strain HMC3 isolated at the Hershey Medical Center, was resistant to vancomycin (VRSA) through the presence of the vanA resistance gene; it also contained mecA, erm(A), erm(B), tet(K) and aac(6′)-aph(2″), conferring resistance to licensed β-lactams, macrolides, tetracycline and aminoglycosides. HMC3 also had alterations in GyrA and GrlB and was resistant to available quinolones. Experimental drugs with low MICs (
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/dkg457