Variability of treatment duration for bacteraemia in the critically ill: a multinational survey

Objectives: No definitive evidence is available to inform ‘best’ antibiotic practice for treating bacteraemia in the critically ill patient, either in terms of duration of therapy, or the use of mono- versus combination therapy. We therefore undertook a large-scale international survey to assess the...

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Bibliographic Details
Published in:	Journal of antimicrobial chemotherapy 2003-11, Vol.52 (5), p.849-852
Main Authors:	Corona, Alberto, Bertolini, Guido, Ricotta, Anna Maria, Wilson, A. J. Peter, Singer, Mervyn
Format:	Article
Language:	eng
Subjects:	Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Antibacterial agents antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteremia - drug therapy Biological and medical sciences Critical Illness Drug Therapy, Combination Health Care Surveys Humans infections intensive care Intensive Care Units Internationality Medical sciences Pharmacology. Drug treatments sepsis Societies, Medical Surveys and Questionnaires Time Factors
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Summary:	Objectives: No definitive evidence is available to inform ‘best’ antibiotic practice for treating bacteraemia in the critically ill patient, either in terms of duration of therapy, or the use of mono- versus combination therapy. We therefore undertook a large-scale international survey to assess the variability of current practice. Methods: A questionnaire was sent to membership lists of national and international intensive care societies. Results: Responses from 254 intensive care units in 34 countries revealed a wide variation in antibiotic strategy for all types of bacteraemia, ranging from short course (≤5 days) therapy with restricted-spectrum antibiotics, to long course (≥10 days) use of broad-spectrum combinations. Two factors were significantly associated with antibiotic prescribing practice, namely the country of origin (in those with ≥10 responders) and the level of microbiologist and/or infectious diseases specialist input. The greater the specialist input, the shorter the duration of therapy (P < 0.0001). Conclusions: The wide variability in antibiotic prescribing patterns suggests an urgent need to produce high-quality evidence to identify optimal antibiotic prescribing policies for bacteraemia in the critically ill patient.
ISSN:	0305-7453 1460-2091 1460-2091