NACP-REP1 polymorphism is not involved in Parkinson's disease: a case-control study in a population sample from southern Italy

Contradictory evidence has been reported on the role of the polymorphic mixed dinucleotide repeat (NACP-REP1) of the α-synuclein gene as a risk factor for sporadic Parkinson's disease (PD). In the present study we genotyped the NACP-REP1 polymorphism in 189 PD patients from southern Italy and 1...

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Bibliographic Details
Published in:Neuroscience letters 2003-11, Vol.351 (2), p.75-78
Main Authors: Spadafora, P., Annesi, G., Pasqua, A.A., Serra, P., Cirò Candiano, I.C., Carrideo, S., Tarantino, P., Civitelli, D., De Marco, E.V., Nicoletti, G., Annesi, F., Quattrone, A.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
alpha-Synuclein
Biological and medical sciences
Case-Control Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dinucleotide Repeats - genetics
Female
Gene Frequency - genetics
Genetic Predisposition to Disease - genetics
Genetic Testing
Genotype
Humans
Italy - epidemiology
Male
Medical sciences
Middle Aged
NACP-REP1
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - genetics
Neurology
Parkinson Disease - epidemiology
Parkinson Disease - genetics
Parkinson's disease (PD)
Polymorphism
Polymorphism, Genetic - genetics
Synucleins
α-synuclein (SNCA)
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Summary:Contradictory evidence has been reported on the role of the polymorphic mixed dinucleotide repeat (NACP-REP1) of the α-synuclein gene as a risk factor for sporadic Parkinson's disease (PD). In the present study we genotyped the NACP-REP1 polymorphism in 189 PD patients from southern Italy and 182 healthy control subjects. We failed to demonstrate an association of any NACP-REP1 allele with PD.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(03)00859-0