Increased Myocardial Uptake of Iodine-123 Metaiodobenzylguanidine on Delayed Images, Compared With Early Images, in Patients With Multiple System Atrophy

We present 2 interesting cases of multiple system atrophy in which increased myocardial iodine-123 metaiodobenzylguanidine uptake was observed on delayed images (3 hours after injection) compared with early images (15 minutes after injection). These findings have not been previously described. The d...

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Bibliographic Details
Published in:Clinical nuclear medicine 2003-11, Vol.28 (11), p.890-892
Main Authors: Ichikawa, Yasutaka, Takeda, Kan, Murashima, Shuichi, Sakuma, Hajime, Matsumura, Kaname, Hirano, Tadanori, Kuzuhara, Shigeki
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Biological and medical sciences
Female
Heart - diagnostic imaging
Humans
Iodine Radioisotopes
Male
Medical sciences
Middle Aged
Multiple System Atrophy - diagnostic imaging
Radionuclide Imaging
Radiopharmaceuticals
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Technology. Biomaterials. Equipments. Material. Instrumentation
Time Factors
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Summary:We present 2 interesting cases of multiple system atrophy in which increased myocardial iodine-123 metaiodobenzylguanidine uptake was observed on delayed images (3 hours after injection) compared with early images (15 minutes after injection). These findings have not been previously described. The duration of symptoms was less than 1 year in both these patients. The mechanism responsible for these findings is not clearly understood, but could be related to the pathophysiological changes in the early stage of multiple systemic atrophy.
ISSN:0363-9762
1536-0229
DOI:10.1097/01.rlu.0000093283.50688.b2