Family study of the aggregation of eating disorders and mood disorders

Background. Family studies have suggested that eating disorders and mood disorders may coaggregate in families. To study further this question, data from a family interview study of probands with and without major depressive disorder was examined. Method. A bivariate proband predictive logistic regr...

Full description

Saved in:
Bibliographic Details
Published in:Psychological medicine 2003-10, Vol.33 (7), p.1319-1323
Main Authors: MANGWETH, B., HUDSON, J. I., POPE, H. G., HAUSMANN, A., De COL, C., LAIRD, N. M., BEIBL, W., TSUANG, M. T.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Affective disorders
Aggregation
Anorexia
Anorexia Nervosa - diagnosis
Anorexia Nervosa - epidemiology
Anorexia Nervosa - genetics
Anorexia Nervosa - psychology
Austria
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - diagnosis
Bipolar Disorder - epidemiology
Bipolar Disorder - genetics
Bipolar Disorder - psychology
Brief Communication
Bulimia
Bulimia - diagnosis
Bulimia - epidemiology
Bulimia - genetics
Bulimia - psychology
Causality
Comorbidity
Depression
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - epidemiology
Depressive Disorder, Major - genetics
Depressive Disorder, Major - psychology
Eating behavior disorders
Eating disorders
Emotional disorders
Families & family life
Family studies
Female
Hospitals
Humans
Innsbruck
Interview, Psychological
Interviews
Logistic Models
Male
Medical sciences
Mental depression
Middle Aged
Miscellaneous
Mood disorders
Odds Ratio
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Regression analysis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Family studies have suggested that eating disorders and mood disorders may coaggregate in families. To study further this question, data from a family interview study of probands with and without major depressive disorder was examined. Method. A bivariate proband predictive logistic regression model was applied to data from a family interview study, conducted in Innsbruck, Austria, of probands with (N=64) and without (N=58) major depressive disorder, together with 330 of their first-degree relatives. Results. The estimated odds ratio (OR) for the familial aggregation of eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) was 7·0 (95% CI 1·4, 28; P=0·006); the OR for the familial aggregation of mood disorders (major depression and bipolar disorder) was 2·2 (0·92, 5·4; P=0·076); and for the familial coaggregation of eating disorders with mood disorders the OR was 2·2 (1·1, 4·6; P=0·035). Conclusions. The familial coaggregation of eating disorders with mood disorders was significant and of the same magnitude as the aggregation of mood disorders alone – suggesting that eating disorders and mood disorders have common familial causal factors.
ISSN:0033-2917
1469-8978
DOI:10.1017/S0033291703008250