Partial protective effect of inactivated Japanese encephalitis vaccine on lethal West Nile virus infection in mice

The effect of mouse brain-derived, inactivated Japanese encephalitis (JE) vaccine on West Nile virus (WNV) infection was examined using a murine model. Mice were immunized with JE vaccine twice and challenged with lethal doses of WNV. When mice were intracranially challenged with WNV, none of the im...

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Bibliographic Details
Published in:Vaccine 2003-11, Vol.21 (31), p.4514-4518
Main Authors: Takasaki, Tomohiko, Yabe, Sadao, Nerome, Reiko, Ito, Mikako, Yamada, Ken-Ichiro, Kurane, Ichiro
Format: Article
Language:English
Subjects:
Animals
Animals, Suckling
Arboviral encephalitis
Arboviroses
Biological and medical sciences
Brain
Brain research
Cross Reactions
Encephalitis
Experiments
Flaviviridae
Fundamental and applied biological sciences. Psychology
Human viral diseases
Infections
Infectious diseases
Injections
Injections, Intraperitoneal
Japanese Encephalitis Vaccines - therapeutic use
Japanese encephalitis virus
Medical sciences
Mice
Microbiology
Neutralization Tests
Tropical viral diseases
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, Inactivated
Viral diseases
Virology
West Nile Fever - prevention & control
West Nile virus
West Nile virus - pathogenicity
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Summary:The effect of mouse brain-derived, inactivated Japanese encephalitis (JE) vaccine on West Nile virus (WNV) infection was examined using a murine model. Mice were immunized with JE vaccine twice and challenged with lethal doses of WNV. When mice were intracranially challenged with WNV, none of the immunized mice were protected. When mice were intraperitoneally challenged, the immunized mice were protected at higher immunization levels. Cross-reactive neutralizing antibodies to WNV were induced by immunization with JE vaccine; however, the levels were much lower than those to JEV. These results indicate that the currently available mouse brain-derived inactivated JE vaccine can induce partial protective immunity to WNV in mice.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(03)00507-3