EFFECT OF NEONATAL INTERLEUKIN-6 (IL-6) TREATMENT (HORMONAL IMPRINTING) ON THE IL-6 CONTENT AND LOCALIZATION OF THE PERITONEAL, BLOOD AND THYMIC CELLS OF ADULT RATS. A CONFOCAL MICROSCOPIC ANALYSIS

Single treatment of newborn rat with human recombinant interleukin-6 (IL-6) durably increases IL-6 content in certain cell types of the adult animal. Peritoneal mast cells contain a high quantity of IL-6, in contrast to controls which contain no IL-6. In addition, many other (mainly lymphatic) cells...

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Bibliographic Details
Published in:	Cell biology international 2001-11, Vol.25 (11), p.1179-1182
Main Authors:	Csaba, György, Kovács, Péter
Format:	Article
Language:	eng
Subjects:	Aging - physiology Animals Animals, Newborn cytokines Female hormonal imprinting IL-6 Immunohistochemistry interleukin-6 Interleukin-6 - administration & dosage Interleukin-6 - blood Interleukin-6 - physiology lymphocytes Lymphocytes - physiology mast cells Mast Cells - physiology Microscopy, Confocal Peritoneal Cavity - cytology Peritoneal Cavity - physiology Rats Rats, Wistar Thymus Gland - cytology Thymus Gland - physiology Time Factors
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Summary:	Single treatment of newborn rat with human recombinant interleukin-6 (IL-6) durably increases IL-6 content in certain cell types of the adult animal. Peritoneal mast cells contain a high quantity of IL-6, in contrast to controls which contain no IL-6. In addition, many other (mainly lymphatic) cells of the peritoneal fluid contain IL-6. However, IL-6 is present in the control thymocytes, in smaller amounts than in the neonatally IL-6 imprinted cells. In the blood, the number of IL-6 containing cells also increases after imprinting (lymphocytes and developing forms of mast cells).
ISSN:	1065-6995 1095-8355