A case of mixed connective tissue disease showing a lymphoid follicle in muscle pathology

We report a 74-year-old man suffering from mixed connective tissue disease (MCTD) accompanied by a lymphoid follicle in muscle pathology. He showed proximal muscle weakness and arthritis in finger joints. His laboratory findings were characteristic of MCTD. Prednisolone administration favorably impr...

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Bibliographic Details
Published in:Journal of the neurological sciences 2003-11, Vol.215 (1), p.119-121
Main Authors: Inoue, Chieko, Ikeda, Yoshio, Tanaka, Makoto, Sakazume, Yuka, Okamoto, Koichi
Format: Article
Language:English
Subjects:
Adhesion molecule
Aged
Biological and medical sciences
Humans
Immunohistochemistry
Inflammatory myopathy
Lymphoid follicle
Lymphoid Tissue - pathology
Male
Medical sciences
Mixed connective tissue disease
Mixed Connective Tissue Disease - pathology
Muscle, Skeletal - pathology
Nodular infiltrates
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:We report a 74-year-old man suffering from mixed connective tissue disease (MCTD) accompanied by a lymphoid follicle in muscle pathology. He showed proximal muscle weakness and arthritis in finger joints. His laboratory findings were characteristic of MCTD. Prednisolone administration favorably improved his symptoms. A lymphoid follicle is a rare pathological finding in inflammatory myopathies. The immunohistochemical findings suggest that the lymphoid follicle would be involved in the specific role for the pathogenesis of MCTD.
ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(03)00202-8