Membrane Permeability Modifications Are Involved in Antibiotic Resistance in Klebsiella pneumoniae

Two Klebsiella pneumoniae strains selected according to their high cross-resistance pattern to cephalosporins were characterized by (i) outer membrane protein content such as OmpA or nonspecific porins, (ii) MICs of various cephalosporins and unrelated antibiotics, (iii) β-lactamase production, and...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2000-08, Vol.274 (2), p.496-499
Main Authors: Chevalier, Jacqueline, Pagès, Jean-Marie, Eyraud, Annie, Malléa, Monique
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - metabolism
Anti-Infective Agents - pharmacokinetics
Anti-Infective Agents - pharmacology
antibiotics
Bacterial Outer Membrane Proteins - analysis
beta-Lactamases - metabolism
Cell Membrane Permeability - drug effects
Cell Membrane Permeability - physiology
Drug Resistance, Microbial - physiology
efflux
Enterobacteriaceae
Imipenem - pharmacology
Klebsiella pneumoniae
Klebsiella pneumoniae - chemistry
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - metabolism
membrane permeability
Microbial Sensitivity Tests
Norfloxacin - pharmacokinetics
porins
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Summary:Two Klebsiella pneumoniae strains selected according to their high cross-resistance pattern to cephalosporins were characterized by (i) outer membrane protein content such as OmpA or nonspecific porins, (ii) MICs of various cephalosporins and unrelated antibiotics, (iii) β-lactamase production, and (iv) active efflux of fluoroquinolones. An association of porin deficiency and β-lactamase production induced a noticeable cephalosporin resistance. In addition to these mechanisms, the presence of an active efflux participating in high-level fluoroquinolone resistance was identified in one strain. The decrease of antibiotic uptake associated with efflux explains the Klebsiella adaptation against the drugs present in the environment.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.2000.3159