Hepatocytes from non-hepatic adult stem cells

Stem cells are undifferentiated long-lived cells that are capable of many rounds of division. Here we show that adult human liver cells can be derived from stem cells originating in the bone marrow or circulating outside the liver, raising the possibility that blood-system stem cells could be used c...

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Bibliographic Details
Published in:Nature (London) 2000-07, Vol.406 (6793), p.257-257
Main Authors: ALISON, M. R, POULSOM, R, JEFFERY, R, DHILLON, A. P, QUAGLIA, A, JACOB, J, NOVELLI, M, PRENTICE, G, WILLIAMSON, J, WRIGHT, N. A
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Bone Marrow Transplantation
Cell Differentiation
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Female
Fundamental and applied biological sciences. Psychology
Hematopoietic Stem Cells - cytology
Humans
Liver - cytology
Male
Molecular and cellular biology
Transplantation Chimera
Y Chromosome
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Summary:Stem cells are undifferentiated long-lived cells that are capable of many rounds of division. Here we show that adult human liver cells can be derived from stem cells originating in the bone marrow or circulating outside the liver, raising the possibility that blood-system stem cells could be used clinically to generate hepatocytes for replacing damaged tissue.
ISSN:0028-0836
1476-4687
DOI:10.1038/35018642