Role of hepatic lipogenesis in the susceptibility to fatty liver in the goose ( Anser anser)

In response to overfeeding, the Landes goose develops a fatty liver that is twice as large as that of the Poland goose, despite similar food intake. The role of hepatic lipogenesis in the genetic susceptibility to fatty liver was assessed in male overfed geese of the two breeds. For a similar hepati...

Full description

Saved in:
Bibliographic Details
Published in:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2000-05, Vol.126 (1), p.81-87
Main Authors: Mourot, Jacques, Guy, Gérard, Lagarrigue, Sandrine, Peiniau, Philippe, Hermier, Dominique
Format: Article
Language:English
Subjects:
Acetyl-CoA Carboxylase - metabolism
Animals
Anser anser
Bird Diseases - metabolism
Body Composition
Computer Science
Disease Susceptibility
Fatty Acid Synthases - metabolism
Fatty Liver - metabolism
Fatty Liver - veterinary
Freshwater
Geese - metabolism
Genetic Predisposition to Disease
Genetics
Glucosephosphate Dehydrogenase - metabolism
Goose
Hepatic steatosis
Life Sciences
Lipogenesis
Lipoproteins, VLDL - analysis
Liver
Liver - metabolism
Malate Dehydrogenase - metabolism
Male
Malic enzyme
Overfeeding
VLDL
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In response to overfeeding, the Landes goose develops a fatty liver that is twice as large as that of the Poland goose, despite similar food intake. The role of hepatic lipogenesis in the genetic susceptibility to fatty liver was assessed in male overfed geese of the two breeds. For a similar hepatic protein content, total activities of malic enzyme, glucose-6-phosphate dehydrogenase, acetyl-Coa-carboxylase and fatty acid synthase, and specific activity and mRNA level of malic enzyme were about two-fold higher in the Landes goose. In the Poland goose, the weight of the fatty liver was correlated positively with the specific activity of ME and the VLDL concentration, which was not the case in the Landes breed. These results show that: (1) hepatic lipogenesis remains very active until the end of the overfeeding period; (2) the pentose-phosphate pathway may function in birds, contrary to what is assumed usually; (3) the level of hepatic lipogenesis is a major factor in the susceptibility to hepatic steatosis in different breeds of geese; and (4) ME activity may be a limiting factor of lipid synthesis in the less susceptible Poland breed.
ISSN:1096-4959
0305-0491
1879-1107
DOI:10.1016/S0305-0491(00)00171-1