Anordiol produces pregnancy loss in the rat—via the embryo or via the uterus?

Anordiol, the dihydroxylated metabolite of anordrin, is an antiestrogen with estrogenic activity that is known to inhibit fertility. The following study was conducted to determine the mechanism of this antifertility effect. Anordiol was administered orally to rats, prior to implantation, on Day 2 of...

Full description

Saved in:
Bibliographic Details
Published in:Contraception (Stoneham) 2000-05, Vol.61 (5), p.341-346
Main Authors: Kaplan-Kraicer, Ruth, Shinnar, Nili, Bardin, C.Wayne, Shalgi, Ruth
Format: Article
Language:English
Subjects:
Abortion, Induced
Animals
anordiol
Biological and medical sciences
Birth control
Blastocyst
Contraceptives, Postcoital - pharmacology
Embryo Implantation - drug effects
Embryo Transfer
Embryo, Mammalian - drug effects
Female
Gestational Age
Gynecology. Andrology. Obstetrics
Induced abortion. Therapeutic abortion
Medical sciences
Norandrostanes - pharmacology
Pregnancy
rat
Rats
Rats, Wistar
Uterus - drug effects
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anordiol, the dihydroxylated metabolite of anordrin, is an antiestrogen with estrogenic activity that is known to inhibit fertility. The following study was conducted to determine the mechanism of this antifertility effect. Anordiol was administered orally to rats, prior to implantation, on Day 2 of pregnancy. Control animals were treated with the vehicle only. The effectiveness of the agent in terminating pregnancy was determined on Day 14 of pregnancy. Anordiol was 100% effective in abolishing pregnancy at a dose of 0.6 mg/Kg. Administration of smaller doses resulted in a decreased number of implanting embryos, in a dose-dependent manner. An additional dose of anordiol on Day 3 of pregnancy yielded similar results. To determine whether pregnancy impairment by anordiol is exerted via the embryo or via the uterus, reciprocal embryo transfers were performed. Day 5 blastocysts were transferred into the uteri of pseudopregnant rats. In one set of experiments, the donor rats were treated with anordiol, and in the second set the recipient rats were treated. The results indicate that the effects of anordiol administration are exerted via the embryo as well as the uterus.
ISSN:0010-7824
1879-0518
DOI:10.1016/S0010-7824(00)00115-3