Endogenous Skin Fluorescence is a Good Marker for Objective Evaluation of Comedolysis

Objective evaluation of comedone lesions, especially in vivo, remains a challenge. We have used the rhino mouse model in combination with topical application of all-trans retinoic acid as a comedolytic agent, to investigate the potential of fluorescence spectroscopy as a noninvasive technique in the...

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Bibliographic Details
Published in:Journal of investigative dermatology 2000-07, Vol.115 (1), p.100-105
Main Authors: González, Salvador, Zonios, George, Nguyen, Bach Cuc, Gillies, Robert, Kollias, Nikiforos
Format: Article
Language:English
Subjects:
acne
Acne Vulgaris - pathology
Acne Vulgaris - prevention & control
Administration, Topical
Animals
Biological and medical sciences
Biomarkers - analysis
comedones
Dermatology
fluorescence spectroscopy
Medical sciences
Mice
retinoids
rhino mouse
Skin - pathology
Skin - radiation effects
Skin involvement in other diseases. Miscellaneous. General aspects
Spectrometry, Fluorescence
Tretinoin - administration & dosage
Tretinoin - therapeutic use
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Summary:Objective evaluation of comedone lesions, especially in vivo, remains a challenge. We have used the rhino mouse model in combination with topical application of all-trans retinoic acid as a comedolytic agent, to investigate the potential of fluorescence spectroscopy as a noninvasive technique in the assessment of noninflammatory acne. The results indicate that there is a strong correlation between the fluorescence excitation spectral features assessed in vivo, and the histologic changes identified, particularly the size of the utriculi as well as the dermal and epidermal thickness. We conclude that fluorescence excitation spectroscopy represents a promising novel and useful tool in the quantitative evaluation of the pseudocomedones and could also be used for the rapid and noninvasive assessment of comedolysis induced by the application of pharmacologic agents such as retinoids.
ISSN:0022-202X
1523-1747
DOI:10.1046/j.1523-1747.2000.00025.x