Serum Lp(a) Lipoprotein Levels in Patients with Atherosclerotic Occlusive Disease of the Lower Extremities

Objective to evaluate the association between Lp(a) lipoprotein levels, other serum lipids and the presence of lower limb atherosclerotic occlusive disease. Materials and methods angiographic findings in 36 patients were related to serum Lp(a). Total cholesterol, triglycerides, LDL-cholesterol, HDL-...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2000-07, Vol.20 (1), p.57-60
Main Authors: Dionyssiou-Asteriou, A., Papastamatiou, M., Vatalas, I.-A., Bastounis, E.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Arteriosclerosis - blood
Arteriosclerosis - diagnosis
Atherosclerotic occlusive disease
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Female
High density lipoprotein (HDL)
Humans
Ischemia - blood
Ischemia - diagnosis
Leg - blood supply
Lipoprotein (a) (Lp(a))
Lipoprotein(a) - blood
Male
Middle Aged
Peripheral vascular disease (PVD)
Triglycerides - blood
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Summary:Objective to evaluate the association between Lp(a) lipoprotein levels, other serum lipids and the presence of lower limb atherosclerotic occlusive disease. Materials and methods angiographic findings in 36 patients were related to serum Lp(a). Total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol and Lp(a) levels were compared with those of 73 age- and sex-matched healthy controls. Results atheromatous lesions were localised in the femoropopliteal (≈60%) and aortoiliac (≈40%) segments. The number of stenosed arteries was ≥2 and the range of stenosis severity was between 40% and 100%. There was a significant increase in serum Lp(a) (p= 0.000001) and a decrease in serum HDL (p= 0.000009) levels in patients compared to controls. No difference was observed in total cholesterol, LDL-cholesterol or triglyceride. However, the ratio of total cholesterol/HDL-cholesterol was significantly higher (p= 0.005) in patients. Conclusion a dyslipidaemic serum profile, characterised by increased Lp(a) levels and decreased HDL-cholesterol levels, is associated with atherosclerotic occlusive disease of the lower extremities.
ISSN:1078-5884
1532-2165
DOI:10.1053/ejvs.2000.1100