344C/T polymorphism of CYP11B2 gene in Italian patients with idiopathic low renin hypertension

Most patients with low renin essential hypertension are not qualitatively different from patients with idiopathic hyperaldosteronism, as in both conditions aldosterone secretion is not appropriately reduced. The aim of the study was to investigate allele and genotype frequencies of the −344C/T polym...

Full description

Saved in:
Bibliographic Details
Published in:American journal of hypertension 2001-09, Vol.14 (9), p.934-941
Main Authors: Rossi, Ermanno, Regolisti, Giuseppe, Perazzoli, Franco, Negro, Aurelio, Davoli, Simona, Nicoli, Davide, Sani, Carlo, Casali, Bruno
Format: Article
Language:English
Subjects:
Aldosterone - blood
Aldosterone - genetics
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Captopril - therapeutic use
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
CYP11B2 polymorphism
Cytochrome P-450 CYP11B2 - drug effects
Cytochrome P-450 CYP11B2 - genetics
Gene Frequency - drug effects
Gene Frequency - genetics
Genotype
Humans
Hypertension - blood
Hypertension - drug therapy
Hypertension - etiology
idiopathic hyperaldosteronism
Italy
low renin essential hypertension
Medical sciences
Polymorphism, Genetic - drug effects
Polymorphism, Genetic - genetics
Potassium - blood
Renin - blood
Renin - drug effects
Renin - genetics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Most patients with low renin essential hypertension are not qualitatively different from patients with idiopathic hyperaldosteronism, as in both conditions aldosterone secretion is not appropriately reduced. The aim of the study was to investigate allele and genotype frequencies of the −344C/T polymorphism, located in the promoter region of the aldosterone synthase gene, in 83 patients with idiopathic low renin hypertension characterized by an increased aldosterone to renin ratio, including both patients with low renin essential hypertension ( n = 53) and subjects with idiopathic hyperaldosteronism ( n = 30), compared with 78 patients with normal to high renin essential hypertension and 126 normotensive control subjects. The relationship of −344C/T genotypes to basal and post-captopril plasma aldosterone/plasma renin activity ratio was also examined in the entire hypertensive population. An increased frequency of the T allele and a relative excess of TT homozygosity over CC homozygosity were found in patients with idiopathic low renin hypertension in comparison with both normal to high renin hypertensives and normotensive controls. A higher post-captopril aldosterone to renin ratio was found in the hypertensives with TT genotype than in those with CC genotype, and TT+TC genotypes were associated with a smaller decrease in the aldosterone-to-renin ratio elicited by captopril administration. The present study suggests that the −344C/T polymorphism, or a functional variant in linkage disequilibrium with it, may play a role in the abnormal regulation of aldosterone secretion in idiopathic low renin hypertension.
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/S0895-7061(01)02138-0