Impact of zanamivir treatment on productivity, health status and healthcare resource use in patients with influenza. Zanamivir Study Group

This study examined the impact of zanamivir treatment on patient morbidity in patients with influenza. This was a multicentre, randomised, double-blind, parallel-group study conducted in 14 countries in Europe and North America during the winter of 1995/1996. The study included 722 individuals with...

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Bibliographic Details
Published in:PharmacoEconomics 2000-02, Vol.17 (2), p.187-195
Main Authors: Aoki, F Y, Fleming, D M, Griffin, A D, Lacey, L A, Edmundson, S
Format: Article
Language:English
Subjects:
Adult
Antiviral Agents - administration & dosage
Antiviral Agents - economics
Antiviral Agents - therapeutic use
Double-Blind Method
Efficiency
Female
Guanidines
Health Care Rationing
Health Status
Health technology assessment
Humans
Influenza, Human - drug therapy
Influenza, Human - economics
Male
Pyrans
Sialic Acids - administration & dosage
Sialic Acids - economics
Sialic Acids - therapeutic use
Zanamivir
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Summary:This study examined the impact of zanamivir treatment on patient morbidity in patients with influenza. This was a multicentre, randomised, double-blind, parallel-group study conducted in 14 countries in Europe and North America during the winter of 1995/1996. The study included 722 individuals with virologically confirmed influenza. Two different zanamivir treatment regimens [twice daily (bid) or 4 times daily (qid) for 5 days] were compared with placebo. Efficacy was measured using a number of patient-assessment questionnaires. Results showed that significantly fewer patients with influenza who were treated with zanamivir had additional contacts with healthcare professionals compared with those who received placebo (8 vs 14%; p < or = 0.049, bid and qid vs placebo). Individuals treated with zanamivir also spent fewer days absent from work (placebo: mean = 3.28 days; qid: mean = 2.52 days; p = 0.031) or college/school (placebo: mean = 2.90 days; bid: mean = 2.24 days; p = 0.032), and showed significant improvements in productivity compared with placebo. The health status questionnaire revealed significant improvements in patient well-being over the first 5 days of the study in those treated with zanamivir compared with those who received placebo. Zanamivir treatment reduced absenteeism, improved patient productivity and well-being, and reduced the additional use of healthcare resources in patients with influenza.
ISSN:1170-7690
1179-2027