Prevalence of G-6-PD Deficiency in the Croatian Adriatic Coast Population

The objective of this study was to determine the prevalence of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency among the population of the Croatian Adriatic Coast, part of the Mediterranean basin. The fluorescent spot test was used to screen 2,726 randomly selected high school students in the...

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Bibliographic Details
Published in:Archives of medical research 2001-09, Vol.32 (5), p.454-457
Main Authors: Krželj, Vjekoslav, Zlodre, Sanja, Terzic, Janoš, Meštrovic, Marija, Jakšic, Jasminka, Pavlov, Neven
Format: Article
Language:English
Subjects:
Adolescent
Croatia - epidemiology
Croatian Adriatic Coast
Female
Fluorescent spot test
G-6-PD deficiency
Glucosephosphate Dehydrogenase - blood
Glucosephosphate Dehydrogenase Deficiency - epidemiology
Humans
Male
Prevalence
Screening
Spectrometry, Fluorescence
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Summary:The objective of this study was to determine the prevalence of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency among the population of the Croatian Adriatic Coast, part of the Mediterranean basin. The fluorescent spot test was used to screen 2,726 randomly selected high school students in the Croatian Adriatic coastal area. Fluorescence readings were performed at the beginning and at 3, 6, 10, and 25 min of incubation. Results were classified into the following three groups: bright fluorescence (BF), weak fluorescence (WF), and no fluorescence (NF). All NF and WF samples at 3 min were quantitatively measured using the spectrophotometric method. Twelve persons, 10 boys and 2 girls, were found to be deficient in G-6-PD, rendering a 0.44% prevalence of G-6-PD deficiency. All NF samples at fluorescent spot test were G-6-PD-deficient. WF at 3 min of the incubation period was present in 33 (1.2%) subjects, and only 2 (6%) were true positive. Fluorescence reading at 10 min of incubation omits five (41%) of the G-6-PD deficient samples. Prevalence of G-6-PD deficiency in the Croatian Adriatic coastal population is 0.44%. Fluorescent spot test for moderate enzyme deficiency is reliable in early fluorescence reading.
ISSN:0188-4409
1873-5487
DOI:10.1016/S0188-4409(01)00301-0