Rates of progression of coronary calcium by electron beam tomography

In this study, we sought to determine the rate of progression of atherosclerosis using coronary calcium scores derived from electron beam tomography (EBT). We studied a variety of disease states (hypertension, high cholesterol, tobacco use, diabetes mellitus) followed for 1 to 6.5 years. We evaluate...

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Bibliographic Details
Published in:The American journal of cardiology 2000-07, Vol.86 (1), p.8-11
Main Authors: Budoff, Matthew J, Lane, Kathleen L, Bakhsheshi, Hamid, Mao, Songshou, Grassmann, Bryan O, Friedman, Bruce C, Brundage, Bruce H
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Calcinosis - diagnostic imaging
Calcinosis - drug therapy
Calcinosis - physiopathology
Calcium
Cardiology
Cardiovascular disease
Cardiovascular system
Cholesterol - blood
Coronary Angiography
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - drug therapy
Coronary Artery Disease - physiopathology
Coronary Vessels - drug effects
Coronary Vessels - physiopathology
Disease Progression
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Hypercholesterolemia - drug therapy
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Reproducibility of Results
Tomography
Tomography, X-Ray Computed
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Summary:In this study, we sought to determine the rate of progression of atherosclerosis using coronary calcium scores derived from electron beam tomography (EBT). We studied a variety of disease states (hypertension, high cholesterol, tobacco use, diabetes mellitus) followed for 1 to 6.5 years. We evaluated 299 asymptomatic persons (227 men and 72 women) who underwent 2 consecutive EBT scans at least 12 months apart. The average change in the calcium score (Agatston method) for the entire group was 33.2 ± 9.2%/year. The treated group (receiving statins) demonstrated an average increase in calcium scores of 15 ± 8%/year compared with 39 ± 12%/year for untreated patients (p 10 on repeat study. In this study, statin therapy induced a 61% reduction in the rate of coronary calcium progression. This study demonstrates that EBT may be a useful tool in assessing efficacy of different interventions to retard progression of atherosclerosis, noninvasively, over relatively short time periods.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(00)00820-1