RNA polymerase II and the integration of nuclear events

In this review, we discuss recent progress relating to what might be called the integration of nuclear events. Our focus will be on studies aimed at deciphering how RNAP II functions in the various RNA processing reactions needed to synthesize a mature mRNA. Much of what we will discuss is illustrat...

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Bibliographic Details
Published in:Genes & development 2000-06, Vol.14 (12), p.1415-1429
Main Authors: Hirose, Y, Manley, J L
Format: Article
Language:English
Subjects:
Allosteric Site
Animals
Cell Nucleus - enzymology
Genes, Fungal
Models, Genetic
Ribonucleases - metabolism
RNA Polymerase II - physiology
RNA Processing, Post-Transcriptional
RNA Splicing
RNA, Messenger - biosynthesis
Transcription, Genetic
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Summary:In this review, we discuss recent progress relating to what might be called the integration of nuclear events. Our focus will be on studies aimed at deciphering how RNAP II functions in the various RNA processing reactions needed to synthesize a mature mRNA. Much of what we will discuss is illustrated in the model shown in Figure 1. The reader is also referred to several excellent related reviews that have appeared recently.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.14.12.1415