An E2 sub-unit marker vaccine does not prevent horizontal or vertical transmission of classical swine fever virus

An experimental infection with classical swine fever (CSF) virus in E2 sub-unit marker vaccine vaccinated gilts was conducted in order to evaluate the effect of vaccination on virus transmission and course of the disease. Therefore, clinical signs as well as horizontal and vertical virus transmissio...

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Bibliographic Details
Published in:Vaccine 2001-10, Vol.20 (1), p.86-91
Main Authors: Dewulf, J, Laevens, H, Koenen, F, Mintiens, K, de Kruif, A
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - biosynthesis
Antibodies, Viral - blood
Antibodies, Viral - immunology
Bacteriology
Biological and medical sciences
Classical swine fever
Classical Swine Fever - immunology
Classical Swine Fever - prevention & control
Classical Swine Fever - transmission
Classical Swine Fever - virology
Classical Swine Fever Virus - immunology
Disease Transmission, Infectious - prevention & control
Drug Evaluation
Female
Fundamental and applied biological sciences. Psychology
Infectious Disease Transmission, Vertical - prevention & control
Microbiology
Pigs
Pregnancy
Pregnancy Complications, Infectious - virology
Swine fever virus
Vaccination
Vaccination - veterinary
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, Marker
Vaccines, Synthetic - immunology
Viral Envelope Proteins - immunology
Viral Vaccines - immunology
Virology
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Summary:An experimental infection with classical swine fever (CSF) virus in E2 sub-unit marker vaccine vaccinated gilts was conducted in order to evaluate the effect of vaccination on virus transmission and course of the disease. Therefore, clinical signs as well as horizontal and vertical virus transmission were monitored in two inoculated, non-vaccinated and 10 vaccinated conventional gilts, housed in individual sow boxes. Within 10 days post-inoculation, all vaccinated gilts became infected. Depending on the definition of the infectious period, two different estimates of R 0 were calculated ( R 0=14.8 and 3.3), both significantly larger than 1 ( P
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(01)00320-6