Genetic hemochromatosis is a rare disease entity among French Basques: a center-based study from the general hospital of Basque County

A center-based study from the general hospital of Basque country has been performed to evaluate the importance of genetic hemochromatosis among French Basques. A sample of 37 patients from 34 families fulfilling the diagnosis criteria of hemochromatosis was obtained. Only four of them were of Basque...

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Bibliographic Details
Published in:Annals of hematology 2001-08, Vol.80 (8), p.472-473
Main Authors: Bauduer, F, Scribans, C, Renoux, M, Borot, N
Format: Article
Language:English
Subjects:
Adult
Aged
Female
France - ethnology
Genetics, Population
Hemochromatosis - epidemiology
Hemochromatosis - genetics
Humans
Incidence
Male
Middle Aged
Mutation
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Summary:A center-based study from the general hospital of Basque country has been performed to evaluate the importance of genetic hemochromatosis among French Basques. A sample of 37 patients from 34 families fulfilling the diagnosis criteria of hemochromatosis was obtained. Only four of them were of Basque origin: two homozygotes for C282Y, one homozygote for H63D, and one heterozygote for C282Y. These results suggest a significant lower prevalence of genetic hemochromatosis in Basques than in people from other French regions (P=0.001). They underline further the biological specificity of this population.
ISSN:0939-5555
1432-0584