The genetic structure of Mexican Mestizos of different locations: tracking back their origins through MHC genes, blood group systems, and microsatellites

Mexican Mestizos, who are the result of the admixture of Spanish, Indian, and Black genes, were analyzed for different systems. Three populations from geographical distinct areas were studied: the north (State of Nuevo Leon ), the center (State of Guanajuato), and the highlands (mainly Mexico City)....

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Bibliographic Details
Published in:Human immunology 2001-09, Vol.62 (9), p.979-991
Main Authors: Gorodezky, C, Alaez, C, Vázquez-García, M N, de la Rosa, G, Infante, E, Balladares, S, Toribio, R, Pérez-Luque, E, Muñoz, L
Format: Article
Language:English
Subjects:
Adult
Blood Group Antigens - genetics
Female
Genes, MHC Class I - genetics
Genes, MHC Class II - genetics
Haplotypes - genetics
HLA Antigens - genetics
Humans
Indians, North American - genetics
Male
Mexico
Microsatellite Repeats - genetics
Nucleic Acid Hybridization
Oligonucleotide Probes
Polymerase Chain Reaction
Tandem Repeat Sequences - genetics
Tyrosine 3-Monooxygenase - genetics
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Summary:Mexican Mestizos, who are the result of the admixture of Spanish, Indian, and Black genes, were analyzed for different systems. Three populations from geographical distinct areas were studied: the north (State of Nuevo Leon ), the center (State of Guanajuato), and the highlands (mainly Mexico City). Ten blood group systems (N = 229), STRs (N = 107), HLA-A*, B*, C* (N = 116-167), and DRB1, DQA1, and DQB1 (N = 40, 101, 160, respectively) were analyzed in the samples of the highlands. The three groups cluster together in the same branch: Mestizos from Venezuela, Mediterranean and Jews close to the cluster of Orientals, followed by Amerindians. All markers demonstrate that Indian genes are strongly represented in the highlands: Di(a), O, D(-)(+), s, A*0201, *0206, B*1539 (*1541), *3902, *3905, *3512, *3517, *4002, *4005, Cw*0801, *0304, *0401 among others. Cw*0501, *1203, *1204, and *1601 are of White ancestry. The most frequent haplotypes *0407-*03011-*0302 and *0802-*0401-*0402 are of Indian descent as well. The center and mainly the north show a more Caucasian and Semitic profile. The results demonstrate the high variability resulting from interethnic admixture, suggesting that this mechanism is the main factor responsible for the large diversity found in urban populations.
ISSN:0198-8859
1879-1166
DOI:10.1016/S0198-8859(01)00296-8