Relationship of serum C3 to fasting insulin, risk factors and previous ischaemic events in middle-aged men

Aims Serum C3 is a powerful indicator of the risk of myocardial infarction, which correlates with body mass index, serum lipids and blood pressure. This study was performed to ascertain whether such correlations may be explained by an association of C3 with fasting insulin, and to assess comparative...

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Bibliographic Details
Published in:European heart journal 2000-07, Vol.21 (13), p.1081-1090
Main Authors: Muscari, A, Massarelli, G, Bastagli, L, Poggiopollini, G, Tomassetti, V, Drago, G, Martignani, C, Pacilli, P, Boni, P, Puddu, P
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers - blood
Blood Glucose - metabolism
Cardiology. Vascular system
Cholesterol, HDL - blood
Complement C3 - metabolism
Complement-3
Coronary heart disease
Feasibility Studies
Heart
Humans
Hyperinsulinism - blood
Hyperinsulinism - complications
Hyperlipidemias - blood
Hyperlipidemias - complications
insulin
Insulin - blood
Insulin Resistance
Male
Medical sciences
Middle Aged
myocardial infarction
Myocardial Infarction - blood
Prognosis
Recurrence
Retrospective Studies
Risk Factors
Triglycerides - blood
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Summary:Aims Serum C3 is a powerful indicator of the risk of myocardial infarction, which correlates with body mass index, serum lipids and blood pressure. This study was performed to ascertain whether such correlations may be explained by an association of C3 with fasting insulin, and to assess comparatively the relationships of C3 and traditional risk factors to previous myocardial infarction. Methods and Results The fasting levels of C3, insulin, and the main risk factors were evaluated in 1090 unselected men aged 55-64 years, including 129 cases of previous ischaemic events (51 myocardial infarctions). In multivariate analysis C3 was associated with insulin (r=0·27,P
ISSN:0195-668X
1522-9645
DOI:10.1053/euhj.1999.2013