Loading…
Losses of Chromosomal Arms 1p and 19q in the Diagnosis of Oligodendroglioma. A Study of Paraffin-Embedded Sections
Comparative genomic hybridization (CGH), fluorescence in situ hybridization (FISH), polymerase chain reaction–based microsatellite analysis, and p53 sequencing were performed in paraffin-embedded material from 18 oligodendrogliomas and histologically similar astrocytomas. The study was undertaken be...
Saved in:
| Published in: | Modern pathology 2001-09, Vol.14 (9), p.842-853 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c507t-4799eb92278492ad62c35987d5e2f9417be36c5900411133f4b26e223bbca34d3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c507t-4799eb92278492ad62c35987d5e2f9417be36c5900411133f4b26e223bbca34d3 |
| container_end_page | 853 |
| container_issue | 9 |
| container_start_page | 842 |
| container_title | Modern pathology |
| container_volume | 14 |
| creator | Burger, Peter C. Minn, A. Yuriko Smith, Justin S. Borell, Thomas J. Jedlicka, Anne E. Huntley, Brenda K. Goldthwaite, Patricia T. Jenkins, Robert B. Feuerstein, Burt G. |
| description | Comparative genomic hybridization (CGH), fluorescence in situ hybridization (FISH), polymerase chain reaction–based microsatellite analysis, and p53 sequencing were performed in paraffin-embedded material from 18 oligodendrogliomas and histologically similar astrocytomas. The study was undertaken because of evidence that concurrent loss of both the 1p and 19q chromosome arms is a specific marker for oligodendrogliomas. Of the six lesions with a review diagnosis of oligodendroglioma, all had the predicted loss of 1p and 19q seen by CGH, FISH, and polymerase chain reaction. Other lesions, including some considered oligodendroglioma or mixed glioma by the submitting institution, did not. There were no p53 mutations in any of the six oligodendrogliomas, whereas 5 of the 10 remaining, successfully studied cases did have p53 mutations. The results suggest that CGH and FISH performed on current or archival tissue can aid in classification of infiltrating gliomas such as oligodendrogliomas and astrocytomas. The results of the p53 studies are consistent with findings of previous investigations that such mutations are less common in oligodendrogliomas than they are in astrocytomas. |
| doi_str_mv | 10.1038/modpathol.3880400 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71168122</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0893395222037012</els_id><sourcerecordid>998339141</sourcerecordid><originalsourceid>FETCH-LOGICAL-c507t-4799eb92278492ad62c35987d5e2f9417be36c5900411133f4b26e223bbca34d3</originalsourceid><addsrcrecordid>eNp9kUFv1DAQhS0EosvCD-AAsjhwy-Kx4zgWp9XSFqSVilQ4W0482XWV2Fs7qdR_T5ZdtRIHTnOY770ZvUfIe2ArYKL-MkR3sOM-9itR16xk7AVZgBSsYLyWL8mC1VoUQkt-Qd7kfMcYlLLmr8kFgJRKKb0gaRtzxkxjRzf7FIeY42B7uk5DpnCgNjgK-p76QMc90m_e7kLM_i9_0_tddBhcirvez7IVXdPbcXKPx-1Pm2zX-VBcDg06h47eYjv6GPJb8qqzfcZ357kkv68uf22-F9ub6x-b9bZoJVNjUSqtsdGcq7rU3LqKt0LqWjmJvNMlqAZF1UrNWAkAQnRlwyvkXDRNa0XpxJJ8PvkeUryfMI9m8LnFvrcB45SNAqhqmAVL8ukf8C5OKcy_Gc6BQ1npIwQnqE1zYgk7c0h-sOnRADPHNsxTG-bcxqz5eDaemgHds-Ic_wx8OAHBjlPCJ-DZ4Otpj3NODx6Tya3H0KLzaU7TuOj_c_4PKdKkiQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>221214692</pqid></control><display><type>article</type><title>Losses of Chromosomal Arms 1p and 19q in the Diagnosis of Oligodendroglioma. A Study of Paraffin-Embedded Sections</title><source>Springer Nature - Connect here FIRST to enable access</source><creator>Burger, Peter C. ; Minn, A. Yuriko ; Smith, Justin S. ; Borell, Thomas J. ; Jedlicka, Anne E. ; Huntley, Brenda K. ; Goldthwaite, Patricia T. ; Jenkins, Robert B. ; Feuerstein, Burt G.</creator><creatorcontrib>Burger, Peter C. ; Minn, A. Yuriko ; Smith, Justin S. ; Borell, Thomas J. ; Jedlicka, Anne E. ; Huntley, Brenda K. ; Goldthwaite, Patricia T. ; Jenkins, Robert B. ; Feuerstein, Burt G.</creatorcontrib><description>Comparative genomic hybridization (CGH), fluorescence in situ hybridization (FISH), polymerase chain reaction–based microsatellite analysis, and p53 sequencing were performed in paraffin-embedded material from 18 oligodendrogliomas and histologically similar astrocytomas. The study was undertaken because of evidence that concurrent loss of both the 1p and 19q chromosome arms is a specific marker for oligodendrogliomas. Of the six lesions with a review diagnosis of oligodendroglioma, all had the predicted loss of 1p and 19q seen by CGH, FISH, and polymerase chain reaction. Other lesions, including some considered oligodendroglioma or mixed glioma by the submitting institution, did not. There were no p53 mutations in any of the six oligodendrogliomas, whereas 5 of the 10 remaining, successfully studied cases did have p53 mutations. The results suggest that CGH and FISH performed on current or archival tissue can aid in classification of infiltrating gliomas such as oligodendrogliomas and astrocytomas. The results of the p53 studies are consistent with findings of previous investigations that such mutations are less common in oligodendrogliomas than they are in astrocytomas.</description><identifier>ISSN: 0893-3952</identifier><identifier>EISSN: 1530-0285</identifier><identifier>DOI: 10.1038/modpathol.3880400</identifier><identifier>PMID: 11557779</identifier><identifier>CODEN: MODPEO</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Astrocytoma ; Brain Neoplasms - diagnosis ; Brain Neoplasms - genetics ; Brain Neoplasms - metabolism ; Chromosome Deletion ; Chromosomes, Human, Pair 1 - genetics ; Chromosomes, Human, Pair 19 - genetics ; Comparative genomic hybridization ; Diagnosis, Differential ; DNA Mutational Analysis ; DNA, Neoplasm - chemistry ; DNA, Neoplasm - genetics ; Female ; FISH ; Genetics ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Male ; Microtomy ; Middle Aged ; Mutation ; Nucleic Acid Hybridization ; Oligodendroglioma ; Oligodendroglioma - diagnosis ; Oligodendroglioma - genetics ; Oligodendroglioma - metabolism ; Paraffin Embedding ; Tumor Suppressor Protein p53 - analysis ; Tumor Suppressor Protein p53 - genetics</subject><ispartof>Modern pathology, 2001-09, Vol.14 (9), p.842-853</ispartof><rights>2001 United States & Canadian Academy of Pathology</rights><rights>Copyright Nature Publishing Group Sep 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-4799eb92278492ad62c35987d5e2f9417be36c5900411133f4b26e223bbca34d3</citedby><cites>FETCH-LOGICAL-c507t-4799eb92278492ad62c35987d5e2f9417be36c5900411133f4b26e223bbca34d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,2744,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11557779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burger, Peter C.</creatorcontrib><creatorcontrib>Minn, A. Yuriko</creatorcontrib><creatorcontrib>Smith, Justin S.</creatorcontrib><creatorcontrib>Borell, Thomas J.</creatorcontrib><creatorcontrib>Jedlicka, Anne E.</creatorcontrib><creatorcontrib>Huntley, Brenda K.</creatorcontrib><creatorcontrib>Goldthwaite, Patricia T.</creatorcontrib><creatorcontrib>Jenkins, Robert B.</creatorcontrib><creatorcontrib>Feuerstein, Burt G.</creatorcontrib><title>Losses of Chromosomal Arms 1p and 19q in the Diagnosis of Oligodendroglioma. A Study of Paraffin-Embedded Sections</title><title>Modern pathology</title><addtitle>Mod Pathol</addtitle><description>Comparative genomic hybridization (CGH), fluorescence in situ hybridization (FISH), polymerase chain reaction–based microsatellite analysis, and p53 sequencing were performed in paraffin-embedded material from 18 oligodendrogliomas and histologically similar astrocytomas. The study was undertaken because of evidence that concurrent loss of both the 1p and 19q chromosome arms is a specific marker for oligodendrogliomas. Of the six lesions with a review diagnosis of oligodendroglioma, all had the predicted loss of 1p and 19q seen by CGH, FISH, and polymerase chain reaction. Other lesions, including some considered oligodendroglioma or mixed glioma by the submitting institution, did not. There were no p53 mutations in any of the six oligodendrogliomas, whereas 5 of the 10 remaining, successfully studied cases did have p53 mutations. The results suggest that CGH and FISH performed on current or archival tissue can aid in classification of infiltrating gliomas such as oligodendrogliomas and astrocytomas. The results of the p53 studies are consistent with findings of previous investigations that such mutations are less common in oligodendrogliomas than they are in astrocytomas.</description><subject>Adult</subject><subject>Aged</subject><subject>Astrocytoma</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - metabolism</subject><subject>Chromosome Deletion</subject><subject>Chromosomes, Human, Pair 1 - genetics</subject><subject>Chromosomes, Human, Pair 19 - genetics</subject><subject>Comparative genomic hybridization</subject><subject>Diagnosis, Differential</subject><subject>DNA Mutational Analysis</subject><subject>DNA, Neoplasm - chemistry</subject><subject>DNA, Neoplasm - genetics</subject><subject>Female</subject><subject>FISH</subject><subject>Genetics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Male</subject><subject>Microtomy</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Nucleic Acid Hybridization</subject><subject>Oligodendroglioma</subject><subject>Oligodendroglioma - diagnosis</subject><subject>Oligodendroglioma - genetics</subject><subject>Oligodendroglioma - metabolism</subject><subject>Paraffin Embedding</subject><subject>Tumor Suppressor Protein p53 - analysis</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><issn>0893-3952</issn><issn>1530-0285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp9kUFv1DAQhS0EosvCD-AAsjhwy-Kx4zgWp9XSFqSVilQ4W0482XWV2Fs7qdR_T5ZdtRIHTnOY770ZvUfIe2ArYKL-MkR3sOM-9itR16xk7AVZgBSsYLyWL8mC1VoUQkt-Qd7kfMcYlLLmr8kFgJRKKb0gaRtzxkxjRzf7FIeY42B7uk5DpnCgNjgK-p76QMc90m_e7kLM_i9_0_tddBhcirvez7IVXdPbcXKPx-1Pm2zX-VBcDg06h47eYjv6GPJb8qqzfcZ357kkv68uf22-F9ub6x-b9bZoJVNjUSqtsdGcq7rU3LqKt0LqWjmJvNMlqAZF1UrNWAkAQnRlwyvkXDRNa0XpxJJ8PvkeUryfMI9m8LnFvrcB45SNAqhqmAVL8ukf8C5OKcy_Gc6BQ1npIwQnqE1zYgk7c0h-sOnRADPHNsxTG-bcxqz5eDaemgHds-Ic_wx8OAHBjlPCJ-DZ4Otpj3NODx6Tya3H0KLzaU7TuOj_c_4PKdKkiQ</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>Burger, Peter C.</creator><creator>Minn, A. Yuriko</creator><creator>Smith, Justin S.</creator><creator>Borell, Thomas J.</creator><creator>Jedlicka, Anne E.</creator><creator>Huntley, Brenda K.</creator><creator>Goldthwaite, Patricia T.</creator><creator>Jenkins, Robert B.</creator><creator>Feuerstein, Burt G.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20010901</creationdate><title>Losses of Chromosomal Arms 1p and 19q in the Diagnosis of Oligodendroglioma. A Study of Paraffin-Embedded Sections</title><author>Burger, Peter C. ; Minn, A. Yuriko ; Smith, Justin S. ; Borell, Thomas J. ; Jedlicka, Anne E. ; Huntley, Brenda K. ; Goldthwaite, Patricia T. ; Jenkins, Robert B. ; Feuerstein, Burt G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-4799eb92278492ad62c35987d5e2f9417be36c5900411133f4b26e223bbca34d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Astrocytoma</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - metabolism</topic><topic>Chromosome Deletion</topic><topic>Chromosomes, Human, Pair 1 - genetics</topic><topic>Chromosomes, Human, Pair 19 - genetics</topic><topic>Comparative genomic hybridization</topic><topic>Diagnosis, Differential</topic><topic>DNA Mutational Analysis</topic><topic>DNA, Neoplasm - chemistry</topic><topic>DNA, Neoplasm - genetics</topic><topic>Female</topic><topic>FISH</topic><topic>Genetics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Male</topic><topic>Microtomy</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Nucleic Acid Hybridization</topic><topic>Oligodendroglioma</topic><topic>Oligodendroglioma - diagnosis</topic><topic>Oligodendroglioma - genetics</topic><topic>Oligodendroglioma - metabolism</topic><topic>Paraffin Embedding</topic><topic>Tumor Suppressor Protein p53 - analysis</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burger, Peter C.</creatorcontrib><creatorcontrib>Minn, A. Yuriko</creatorcontrib><creatorcontrib>Smith, Justin S.</creatorcontrib><creatorcontrib>Borell, Thomas J.</creatorcontrib><creatorcontrib>Jedlicka, Anne E.</creatorcontrib><creatorcontrib>Huntley, Brenda K.</creatorcontrib><creatorcontrib>Goldthwaite, Patricia T.</creatorcontrib><creatorcontrib>Jenkins, Robert B.</creatorcontrib><creatorcontrib>Feuerstein, Burt G.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Modern pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burger, Peter C.</au><au>Minn, A. Yuriko</au><au>Smith, Justin S.</au><au>Borell, Thomas J.</au><au>Jedlicka, Anne E.</au><au>Huntley, Brenda K.</au><au>Goldthwaite, Patricia T.</au><au>Jenkins, Robert B.</au><au>Feuerstein, Burt G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Losses of Chromosomal Arms 1p and 19q in the Diagnosis of Oligodendroglioma. A Study of Paraffin-Embedded Sections</atitle><jtitle>Modern pathology</jtitle><addtitle>Mod Pathol</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>14</volume><issue>9</issue><spage>842</spage><epage>853</epage><pages>842-853</pages><issn>0893-3952</issn><eissn>1530-0285</eissn><coden>MODPEO</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Comparative genomic hybridization (CGH), fluorescence in situ hybridization (FISH), polymerase chain reaction–based microsatellite analysis, and p53 sequencing were performed in paraffin-embedded material from 18 oligodendrogliomas and histologically similar astrocytomas. The study was undertaken because of evidence that concurrent loss of both the 1p and 19q chromosome arms is a specific marker for oligodendrogliomas. Of the six lesions with a review diagnosis of oligodendroglioma, all had the predicted loss of 1p and 19q seen by CGH, FISH, and polymerase chain reaction. Other lesions, including some considered oligodendroglioma or mixed glioma by the submitting institution, did not. There were no p53 mutations in any of the six oligodendrogliomas, whereas 5 of the 10 remaining, successfully studied cases did have p53 mutations. The results suggest that CGH and FISH performed on current or archival tissue can aid in classification of infiltrating gliomas such as oligodendrogliomas and astrocytomas. The results of the p53 studies are consistent with findings of previous investigations that such mutations are less common in oligodendrogliomas than they are in astrocytomas.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11557779</pmid><doi>10.1038/modpathol.3880400</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-3952 |
| ispartof | Modern pathology, 2001-09, Vol.14 (9), p.842-853 |
| issn | 0893-3952 1530-0285 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71168122 |
| source | Springer Nature - Connect here FIRST to enable access |
| subjects | Adult Aged Astrocytoma Brain Neoplasms - diagnosis Brain Neoplasms - genetics Brain Neoplasms - metabolism Chromosome Deletion Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 19 - genetics Comparative genomic hybridization Diagnosis, Differential DNA Mutational Analysis DNA, Neoplasm - chemistry DNA, Neoplasm - genetics Female FISH Genetics Humans Immunohistochemistry In Situ Hybridization, Fluorescence Male Microtomy Middle Aged Mutation Nucleic Acid Hybridization Oligodendroglioma Oligodendroglioma - diagnosis Oligodendroglioma - genetics Oligodendroglioma - metabolism Paraffin Embedding Tumor Suppressor Protein p53 - analysis Tumor Suppressor Protein p53 - genetics |
| title | Losses of Chromosomal Arms 1p and 19q in the Diagnosis of Oligodendroglioma. A Study of Paraffin-Embedded Sections |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T17%3A28%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Losses%20of%20Chromosomal%20Arms%201p%20and%2019q%20in%20the%20Diagnosis%20of%20Oligodendroglioma.%20A%20Study%20of%20Paraffin-Embedded%20Sections&rft.jtitle=Modern%20pathology&rft.au=Burger,%20Peter%20C.&rft.date=2001-09-01&rft.volume=14&rft.issue=9&rft.spage=842&rft.epage=853&rft.pages=842-853&rft.issn=0893-3952&rft.eissn=1530-0285&rft.coden=MODPEO&rft_id=info:doi/10.1038/modpathol.3880400&rft_dat=%3Cproquest_cross%3E998339141%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c507t-4799eb92278492ad62c35987d5e2f9417be36c5900411133f4b26e223bbca34d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=221214692&rft_id=info:pmid/11557779&rfr_iscdi=true |