Accurate diagnosis helicobacter pylori infection by stool antigen test and 6 other currently available tests in children

Invasive and noninvasive tests have been developed for the diagnosis of Helicobacter pylori infection. Because H pylori infection is acquired in childhood and adolescence, accurate diagnosis of the infection in the pediatric population is important. We conducted a study to compare invasive tests: cu...

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Bibliographic Details
Published in:The Journal of pediatrics 2000-06, Vol.136 (6), p.823-827
Main Authors: Ni, Yen-Hsuan, Lin, Jaw-Town, Huang, Shiu-Feng, Yang, Jyh-Chin, Chang, Mei-Hwei
Format: Article
Language:English
Subjects:
Adolescent
Antigens, Bacterial - analysis
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Biopsy urease test
BUT
Child
Feces - chemistry
Female
Helicobacter Infections - diagnosis
Helicobacter pylori - immunology
Human bacterial diseases
Humans
Immunoglobulin
Infectious diseases
Male
Medical sciences
PCR
Polymerase chain reaction
Predictive Value of Tests
Reproducibility of Results
Sensitivity and Specificity
UBT
Urea breath test
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Summary:Invasive and noninvasive tests have been developed for the diagnosis of Helicobacter pylori infection. Because H pylori infection is acquired in childhood and adolescence, accurate diagnosis of the infection in the pediatric population is important. We conducted a study to compare invasive tests: culture, biopsy urease test, histology, and polymerase chain reaction on gastric biopsy specimens, with noninvasive tests: serology, 13C-urea breath test, and a new diagnostic modality, stool antigen test to diagnose H pylori infection. A total of 53 children with symptoms were enrolled in this study, and all had completed the 7 diagnostic tests for H pylori. All the diagnostic tests except serology were excellent methods of diagnosing H pylori infection in children; the diagnostic accuracy was as follows: stool antigen test 96.2%, biopsy urease test 96.2%, histology 98.1%, polymerase chain reaction 94.3%, culture 98.1%, 13C-urea breath test 100%, and serology 84.9%. The stool antigen test, being highly sensitive and specific, will be potentially very helpful in diagnosing H pylori infection in children. (J Pediatr 2000;136:823-7)
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(00)00880-5