Further characterization of a CNS adenosine A2a receptor ligand [11C]KF18446 with in vitro autoradiography and in vivo tissue uptake

PET assessment of the adenosine A2a receptors localized in the striatum offers us a potential new diagnostic tool for neurological disorders. In the present study, we carried out in vitro receptor autoradiography of a newly developed PET ligand [11C]KF18446 ([7-methyl-11C]-(E)-8-(3,4,5-trimethoxysty...

Full description

Saved in:
Bibliographic Details
Published in:Annals of nuclear medicine 2000-04, Vol.14 (2), p.81-89
Main Authors: Ishiwata, K, Ogi, N, Shimada, J, Nonaka, H, Tanaka, A, Suzuki, F, Senda, M
Format: Article
Language:English
Subjects:
Animals
Autoradiography
Biological Transport, Active
Brain - diagnostic imaging
Brain - metabolism
Carbon Radioisotopes
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - metabolism
Corpus Striatum - diagnostic imaging
Corpus Striatum - metabolism
Humans
In Vitro Techniques
Ligands
Male
Mice
Rats
Rats, Wistar
Receptor, Adenosine A2A
Receptors, Purinergic P1 - metabolism
Tomography, Emission-Computed
Xanthines - metabolism
Xanthines - pharmacokinetics
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PET assessment of the adenosine A2a receptors localized in the striatum offers us a potential new diagnostic tool for neurological disorders. In the present study, we carried out in vitro receptor autoradiography of a newly developed PET ligand [11C]KF18446 ([7-methyl-11C]-(E)-8-(3,4,5-trimethoxystyryl)-1,3,7-trimethylxanthin e) with rat brain sections. [11C]KF18446 showed a high striatum/cortex binding ratio (5.0) and low nonspecific binding (
ISSN:0914-7187
1864-6433
DOI:10.1007/BF02988585