Stereocontrolled Synthesis of the Northern Part of Potent Proteasome Inhibitor TMC-95A

A protected version of the northern part of TMC-95A, a potent and selective proteasome inhibitor, was synthesized with full stereochemical control. Highlights of this synthesis include (i) a (Z)-selective Mizoroki−Heck reaction to construct the oxyindole portion, (ii) a diastereoselective epoxidatio...

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Bibliographic Details

Published in:	Organic letters 2001-09, Vol.3 (18), p.2863-2865
Main Authors:	Inoue, Masayuki, Furuyama, Hidetomo, Sakazaki, Hayato, Hirama, Masahiro
Format:	Article
Language:	English
Subjects:	Cysteine Endopeptidases Molecular Conformation Multienzyme Complexes - antagonists & inhibitors Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Proteasome Endopeptidase Complex
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