Signal transduction by tumor necrosis factor and its relatives

Tumor necrosis factor α (TNFα) is a potent proinflammatory cytokine that plays an important role in immunity and inflammation, and in the control of cell proliferation, differentiation and apoptosis. TNFα is also the founding member of a still growing family of cytokines with diverse bioregulatory f...

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Bibliographic Details
Published in:Trends in Cell Biology 2001-09, Vol.11 (9), p.372-377
Main Authors: Baud, Véronique, Karin, Michael
Format: Article
Language:English
Subjects:
Apoptosis - physiology
Caspases - metabolism
Enzyme Activation - genetics
fas Receptor - metabolism
Inflammation - metabolism
Mitogen-Activated Protein Kinases - metabolism
NF-kappa B - metabolism
Receptors, Tumor Necrosis Factor - metabolism
Signal Transduction - physiology
Transcription Factor AP-1 - metabolism
Tumor Necrosis Factor-alpha - chemistry
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - metabolism
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Summary:Tumor necrosis factor α (TNFα) is a potent proinflammatory cytokine that plays an important role in immunity and inflammation, and in the control of cell proliferation, differentiation and apoptosis. TNFα is also the founding member of a still growing family of cytokines with diverse bioregulatory functions. Considerable progress has been made in understanding the molecular mechanisms that mediate TNFα-induced cellular responses. Binding of TNFα to its two receptors, TNFR1 and TNFR2, results in recruitment of signal transducers that activate at least three distinct effectors. Through complex signaling cascades and networks, these effectors lead to the activation of caspases and two transcription factors, AP-1 and NF-κB. Similar signaling mechanisms are likely to be used by other members of the TNF family. This review focuses on proteins that transduce the signals generated at TNF receptors to nuclear targets such as AP-1 and NF-κB.
ISSN:0962-8924
1879-3088
DOI:10.1016/S0962-8924(01)02064-5