Mass Vaccination of Children with Pertussis Toxoid—Decreased Incidence in Both Vaccinated and Nonvaccinated Persons

During 1979-1995, there was no vaccination against pertussis in Sweden. With the aim of studying the epidemiology and transmission of pertussis, mass vaccination with pertussis toxoid of children born during the 1990s was instituted in the Göteborg area (population, 778,597) in 1995. Infants were of...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases 2001-10, Vol.33 (7), p.1004-1009
Main Authors: Taranger, John, Trollfors, Birger, Bergfors, Elisabet, Knutsson, Nina, Sundh, Valter, Lagergård, Teresa, Lind-Brandberg, Lena, Zackrisson, Gunilla, White, Jo, Cicirello, Helen, Fusco, Joan, Robbins, John B.
Format: Article
Language:English
Subjects:
Adolescent
Antibodies, Bacterial - blood
Bacterial diseases
Bacterial diseases of the respiratory system
Biological and medical sciences
Bordetella pertussis
Bordetella pertussis - immunology
Bordetella pertussis - isolation & purification
Child
Child, Preschool
Children
Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage
Dosage
Epidemiology
Hospitalization
Human bacterial diseases
Humans
Incidence
Infant
Infants
Infectious diseases
Major Articles
Mass immunization
Medical sciences
Pertussis Vaccine - administration & dosage
Pertussis Vaccine - immunology
Sweden - epidemiology
Toxoid vaccines
Toxoids - administration & dosage
Toxoids - immunology
Vaccination
Whooping cough
Whooping Cough - epidemiology
Whooping Cough - microbiology
Whooping Cough - prevention & control
Whooping Cough - transmission
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:During 1979-1995, there was no vaccination against pertussis in Sweden. With the aim of studying the epidemiology and transmission of pertussis, mass vaccination with pertussis toxoid of children born during the 1990s was instituted in the Göteborg area (population, 778,597) in 1995. Infants were offered 3 doses of pertussis toxoid combined with diphtheria and tetanus toxoids. Children aged ≥1 year were offered 3 doses of pertussis toxoid alone. From June 1995 through February 1999, 167,810 doses of pertussis toxoid were given to 61,219 children born during the 1990s (56% received 3 doses). The number of Bordetella pertussis isolates per year declined from 1214 (1993-1995) to 64 (January 1997 through June 1999; P < .0001), and hospitalizations due to pertussis declined from 62 to 5 (P < .0001). Significant decreases in B. pertussis isolates and hospitalizations occurred in all age groups, including adults and nonvaccinated infants. Thus, mass vaccination of children with pertussis toxoid decreases spread of B. pertussis in the population.
ISSN:1058-4838
1537-6591
DOI:10.1086/322639