Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the Framingham study

Some studies show that plasma triglyceride (TG) levels are a significant independent risk factor for cardiovascular disease (CVD). TG levels are inversely correlated with high density lipoprotein cholesterol (HDL-C) levels, and their metabolism may be closely interrelated. Therefore, the TG/HDL-C ra...

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Bibliographic Details
Published in:Human molecular genetics 2000-05, Vol.9 (9), p.1315-1320
Main Authors: Shearman, A M, Ordovas, J M, Cupples, L A, Schaefer, E J, Harmon, M D, Shao, Y, Keen, J D, DeStefano, A L, Joost, O, Wilson, P W, Housman, D E, Myers, R H
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - genetics
Cholesterol, HDL - blood
Cholesterol, HDL - genetics
chromosome 7
Chromosomes, Human, Pair 7
Cohort Studies
Female
Genetic Linkage
Genome, Human
Humans
Lod Score
Male
Middle Aged
Phenotype
triglycerides
Triglycerides - blood
Triglycerides - genetics
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Summary:Some studies show that plasma triglyceride (TG) levels are a significant independent risk factor for cardiovascular disease (CVD). TG levels are inversely correlated with high density lipoprotein cholesterol (HDL-C) levels, and their metabolism may be closely interrelated. Therefore, the TG/HDL-C ratio may be a relevant CVD risk factor. Our analysis of families in the Framingham Heart Study gave a genetic heritability estimate for log(TG) of 0.40 and for log(TG/HDL-C) of 0.49, demonstrating an important genetic component for both. A 10 cM genome-wide scan for log(TG) level and log(TG/HDL-C) was carried out for the largest 332 extended families of the Framingham Heart Study (1702 genotyped individuals). The highest multipoint variance component LOD scores obtained for both log(TG) and log(TG/HDL-C) were on chromosome 7 (at 155 cM), where the results for the two phenotypes were 1.8 and 2.5, respectively. The 7q32.3-qter region contains several candidate genes. Four other regions with multipoint LOD scores greater than one were identified on chromosome 3 [LOD score for log(TG/HDL-C) = 1.8 at 140 cM], chromosome 11 [LOD score for log(TG/HDL-C) = 1.1 at 125 cM], chromosome 16 [LOD score for log(TG) = 1.5 at 70 cM, LOD score for log(TG/HDL-C) = 1.1 at 75 cM] and chromosome 20 [LOD score for log(TG/HDL-C) = 1.7 at 35 cM, LOD score for log(TG) = 1.3 at 40 cM]. These results identify loci worthy of further study.
ISSN:0964-6906
1460-2083
1460-2083
DOI:10.1093/hmg/9.9.1315