Approaches to enhancing the sensitivity of capillary electrophoresis methods for the determination of inorganic and small organic anions

One of the major problems facing the development of capillary electrophoresis (CE) is the relatively high limits of detection when compared to traditional high‐performance liquid chromatographic (HPLC) methods. While the use of an alternative detector can offer better sensitivity, a more universal a...

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Bibliographic Details
Published in:Electrophoresis 2001-07, Vol.22 (12), p.2464-2489
Main Authors: Breadmore, M C, Haddad, P R
Format: Article
Language:English
Subjects:
Anions - analysis
Capillary electrophoresis
Chromatography - methods
Chromatography, Ion Exchange
Chromatography, Liquid
Electrophoresis
Electrophoresis, Capillary - instrumentation
Electrophoresis, Capillary - methods
Forecasting
Hydrogen-Ion Concentration
Inorganic Chemicals - analysis
On-line preconcentration
Organic Chemicals - analysis
Review
Sensitivity and Specificity
Solid-phase extraction
Stacking
Citations: Items that this one cites
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Summary:One of the major problems facing the development of capillary electrophoresis (CE) is the relatively high limits of detection when compared to traditional high‐performance liquid chromatographic (HPLC) methods. While the use of an alternative detector can offer better sensitivity, a more universal approach is sample preconcentration. Numerous on‐line methods have been developed to improve the sensitivity of CE, and are based on electrophoretic principles, chromatographic principles, or a combination of both. This review will discuss all forms of on‐line preconcentration methods for CE, with emphasis given to those that have shown particular merit when applied to inorganic and small organic anions.
ISSN:0173-0835
1522-2683
DOI:10.1002/1522-2683(200107)22:12<2464::AID-ELPS2464>3.0.CO;2-U