Physiological characteristics of platelet/circulatory serotonin: study on a large human population

The aim of this work was the study of platelet/circulatory serotonin (5-hydroxytryptamine, 5-HT), specifically alternative ways of its measurement and main physiological characteristics. The study was performed on a large human population ( N=500) of blood donors of both sexes over the course of a l...

Full description

Saved in:
Bibliographic Details
Published in:Psychiatry research 2000-05, Vol.94 (2), p.153-162
Main Authors: Jernej, Branimir, Banović, Miroslav, Cicin-Šain, Lipa, Hranilović, Dubravka, Balija, Melita, Orešković, Darko, Folnegović-Šmalc, Vera
Format: Article
Language:English
Subjects:
5-HT
Adolescent
Adult
Age Factors
Age influence
Aged
Blood Platelets - metabolism
Female
Humans
Intra-individual stability
Male
Middle Aged
Platelet Count
Platelet serotonin
Reference Values
Seasonal oscillations
Serotonin - blood
Sex Factors
Sex influence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this work was the study of platelet/circulatory serotonin (5-hydroxytryptamine, 5-HT), specifically alternative ways of its measurement and main physiological characteristics. The study was performed on a large human population ( N=500) of blood donors of both sexes over the course of a longer time period (17 months). Owing to the heterogeneity in measurement of circulatory serotonin encountered in the literature, three ways of expression were comparatively studied: per unit number of platelets, per unit mass of platelet protein and per unit volume of whole blood. Results demonstrated unimodal distribution of individual frequencies of platelet/circulatory serotonin in the human population with the mean values of 579±169 ng 5-HT/10 9 platelets; 332±89.9 ng 5-HT/mg protein and 130±42.3 ng 5-HT/ml blood (mean±S.D.). A progressive decrease of serotonin level with age (18–65 years) was demonstrated, reaching statistical significance between the extreme age groups. No significant differences in the serotonin level between the sexes were observed. No seasonal oscillations in platelet/circulatory serotonin were found. Platelet serotonin demonstrated intra-individual stability over time. Finally, regarding the methodology of measurement, our results demonstrated a good correlation among the above-mentioned ways of expression of platelet/circulatory serotonin. This indicates the possibility of intercomparison of the literature reports expressing this physiological parameter either as 5-HT concentration in platelets or as 5-HT level in the circulation.
ISSN:0165-1781
1872-7123
DOI:10.1016/S0165-1781(00)00129-3