Incidence of primary opportunistic infections in two human immunodeficiency virus-infected French clinical cohorts

Background Clinical guidelines for the prevention of opportunistic infections in human immunodeficiency virus (HIV)-infected individuals have been developed on the basis of natural history data collected in the USA. The objective of this study was to estimate the incidence of primary opportunistic i...

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Bibliographic Details
Published in:International journal of epidemiology 2001-08, Vol.30 (4), p.864-871
Main Authors: Yazdanpanah, Yazdan, Chêne, Geneviève, Losina, Elena, Goldie, Sue J, Merchadou, Laurence Dequae, Alfandari, Serge, Seage, George R, Sullivan, Lisa, Marimoutou, Catherine, Paltiel, A David, Salamon, Roger, Mouton, Yves, Freedberg, Kenneth A
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - epidemiology
AIDS-Related Opportunistic Infections - immunology
Biological and medical sciences
CD4 antigen
CD4 Lymphocyte Count
Chi-Square Distribution
Cohort Studies
Female
France
France - epidemiology
HIV
Human immunodeficiency virus
Human viral diseases
Humans
Incidence
incidence rate
Infectious diseases
Male
Medical sciences
Middle Aged
natural history
Opportunistic infections
Risk Factors
Statistics, Nonparametric
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Background Clinical guidelines for the prevention of opportunistic infections in human immunodeficiency virus (HIV)-infected individuals have been developed on the basis of natural history data collected in the USA. The objective of this study was to estimate the incidence of primary opportunistic infections in HIV-infected individuals in geographically distinct cohorts in France. Methods We conducted our study on 2664 HIV-infected patients from the Tourcoing AIDS Reference Centre and the hospital-based information system of the Groupe d'Epidémiologie Clinique du SIDA en Aquitaine enrolled from January 1987 to September 1995 and followed through December 1995. We estimated: (1) CD4-adjusted incidence rates of seven primary opportunistic infections in the absence of prophylaxis for that specific infection or any antiretroviral drugs other than zidovudine; and (2) CD4 lymphocyte count decline. Results The highest incidence rates for all opportunistic infections studied occurred in patients with CD4 counts
ISSN:0300-5771
1464-3685
DOI:10.1093/ije/30.4.864