Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice

Dietary supplementation with nutrients rich in antioxidants is associated with inhibition of atherogenic modifications to LDL, macrophage foam cell formation, and atherosclerosis. Pomegranates are a source of polyphenols and other antioxidants. We analyzed, in healthy male volunteers and in atherosc...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2000-05, Vol.71 (5), p.1062-1076
Main Authors: Aviram, M, Dornfeld, L, Rosenblat, M, Volkova, N, Kaplan, M, Coleman, R, Hayek, T, Presser, D, Fuhrman, B
Format: Article
Language:English
Subjects:
Adult
Animals
Antioxidants
Aorta - pathology
Apolipoproteins E - deficiency
Apolipoproteins E - physiology
Arteriosclerosis - metabolism
Arteriosclerosis - prevention & control
Aryldialkylphosphatase
Benzothiazoles
Beverages
Blood vessels
Diet
Esterases - blood
Flavonoids
Fruit - metabolism
Fruit - physiology
Glutathione - blood
Humans
Indicators and Reagents - chemistry
Lipid Peroxidation - physiology
Lipids
Lipoproteins, HDL - blood
Lipoproteins, LDL - blood
Lipoproteins, LDL - metabolism
Lipoproteins, LDL - physiology
Macrophages, Peritoneal - physiology
Male
Men
Mice
Nutrition
Oxidation
Oxidative Stress - physiology
Phenols - metabolism
Platelet Aggregation - physiology
Polymers - metabolism
Polyphenols
Rodents
Sulfonic Acids - chemistry
Superoxides - analysis
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Summary:Dietary supplementation with nutrients rich in antioxidants is associated with inhibition of atherogenic modifications to LDL, macrophage foam cell formation, and atherosclerosis. Pomegranates are a source of polyphenols and other antioxidants. We analyzed, in healthy male volunteers and in atherosclerotic apolipoprotein E-deficient (E(0)) mice, the effect of pomegranate juice consumption on lipoprotein oxidation, aggregation, and retention; macrophage atherogenicity; platelet aggregation; and atherosclerosis. Potent antioxidative effects of pomegranate juice against lipid peroxidation in whole plasma and in isolated lipoproteins (HDL and LDL) were assessed in humans and in E(0) mice after pomegranate juice consumption for
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/71.5.1062