Antimicrobial Susceptibility of Staphylococcus aureus Isolated from Bovine Mastitis in Europe and the United States

Minimum inhibitory concentrations were determined for 811 strains of Staphylococcus aureus isolated from cases of bovine mastitis in 11 countries. The countries and number of isolates included Denmark (105), England (92), Finland (95), Germany (103), Iceland (22), Ireland (42), Norway (101), Sweden...

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Bibliographic Details
Published in:Journal of dairy science 2000-04, Vol.83 (4), p.855-862
Main Authors: De Oliveira, A.P., Watts, J.L., Salmon, S.A., Aarestrup, F.M.
Format: Article
Language:English
Subjects:
Action of physical and chemical agents on bacteria
Animal productions
Animals
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
antimicrobial susceptibility
Bacteriology
beta-Lactamases - biosynthesis
beta-Lactams
Biological and medical sciences
bovine mastitis
Cattle
Drug Resistance, Microbial
Europe
Female
Food industries
Fundamental and applied biological sciences. Psychology
Mastitis, Bovine - drug therapy
Mastitis, Bovine - microbiology
Microbial Sensitivity Tests
Microbiology
Milk and cheese industries. Ice creams
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcal Infections - veterinary
Staphylococcus aureus
Staphylococcus aureus - drug effects
Terrestrial animal productions
United States
Vertebrates
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Summary:Minimum inhibitory concentrations were determined for 811 strains of Staphylococcus aureus isolated from cases of bovine mastitis in 11 countries. The countries and number of isolates included Denmark (105), England (92), Finland (95), Germany (103), Iceland (22), Ireland (42), Norway (101), Sweden (123), Switzerland (69), United States (53), and Zimbabwe (6). The antimicrobial agents tested were penicillin, ampicillin, oxacillin, cephalothin, ceftiofur, amoxicillin + clavulanate, penicillin + novobiocin, enrofloxacin, premafloxacin, erythromycin, clindamycin, lincomycin, pirlimycin, neomycin, lincomycin + neomycin, and sulfamethazine. The MIC90 for these antimicrobial agents for all strains were 0.5, 1.0, 1.0, 0.5, 1.0, ≤0.06, 0.125, 0.125, ≤0.0078, 0.5, 1.0, 16.0, 1.0, 2.0, 0.5, and 4.0μg/ml, respectively. Overall, only small variations between countries were seen in the MIC90 for the majority of compounds tested. Of the strains tested, 35.6% were positive for β-lactamase production on initial testing, with an additional 21.3% positive after induction by penicillin. In conclusion, the overall level of resistance was generally low for all antimicrobial agents tested regardless of country. Given the differences in antimicrobial use in various countries, the widespread adoption of mastitis control programs to prevent infections limits the exposure of S. aureus infected animals to antimicrobial drugs.
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.S0022-0302(00)74949-6