Influence of age on activities of antioxidant enzymes and lipid peroxidation products in erythrocytes and neutrophils of down syndrome patients

Thirty-seven individuals with Down syndrome (DS) were divided into four age categories: (i) 1 to < 6 years, (ii) 6 to < 13 years, (iii) 13 to < 20 years, and (iv) over 20 years. Activities of antioxidant enzymes found in individual age categories were different, but the differences between...

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Bibliographic Details
Published in:Free radical biology & medicine 2001-08, Vol.31 (4), p.499-508
Main Authors: Muchová, Jana, S̆ustrová, Mária, Garaiová, Iveta, Liptáková, Anna, Blaz̆ı́c̆ek, Pavol, Kvasnic̆ka, Peter, Pueschel, Siegfried, D̆urac̆ková, Zden̆ka
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aging
Aging - metabolism
Antioxidant enzymes
Catalase - blood
Catalase - metabolism
Child
Child, Preschool
Down syndrome
Down Syndrome - enzymology
Erythrocytes - enzymology
Free radicals
Glutathione Peroxidase - metabolism
Glutathione Reductase - metabolism
Humans
Infant
Lipid Peroxides - metabolism
Lipofuscin
Malondialdehyde
Neutrophils - enzymology
Oxidation-Reduction
Oxidoreductases - metabolism
Peroxidase - metabolism
Superoxide Dismutase - metabolism
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Summary:Thirty-seven individuals with Down syndrome (DS) were divided into four age categories: (i) 1 to < 6 years, (ii) 6 to < 13 years, (iii) 13 to < 20 years, and (iv) over 20 years. Activities of antioxidant enzymes found in individual age categories were different, but the differences between age groups were not statistically significant. We confirmed significantly higher activities of Cu/Zn superoxide dismutase (SOD) and glutathione peroxidase (GPx) in blood cells of people with DS as compared to 35 controls, which consisted, for the first time, of siblings of children with DS. No significant differences were found in activities of catalase and glutathione reductase in DS vs. controls. A significant difference was observed in serum concentration of malondialdehyde (MDA) in DS vs. controls (8.39 ± 0.34 μmol/l vs. 7.34 ± 0.27 μmol/l; p = .021) and concentration of MDA in erythrocytes of individuals with DS between the third and fourth age group ( p = .05). In DS persons, an elevated ratio of SOD to catalase plus GPx with respect to the controls in all age categories was found, suggesting oxidative imbalance, potentially contributing to accelerated aging observed in these persons.
ISSN:0891-5849
1873-4596
DOI:10.1016/S0891-5849(01)00609-8