Water soluble polymers in tumor targeted delivery

The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug resistance, preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability, and targetability. The utili...

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Bibliographic Details
Published in:Journal of controlled release 2001-07, Vol.74 (1), p.147-158
Main Authors: Kopeček, J, Kopečková, P, Minko, T, Lu, Z.-R, Peterson, C.M
Format: Article
Language:English
Subjects:
Animals
Antibody fragments
Antineoplastic agents
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacology
Biological and medical sciences
Chemotherapy
Combination therapy
Combined treatments (chemotherapy of immunotherapy associated with an other treatment)
Drug Delivery Systems
Female
General pharmacology
Hempa
HPMA copolymers
Humans
Long-circulating macromolecular therapeutics
Medical sciences
Mice
Mice, Nude
Neoplasm Transplantation
Ovarian carcinoma
Ovarian Neoplasms - drug therapy
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Photodynamic therapy
PK1
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Summary:The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug resistance, preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability, and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model, which combines chemotherapy and photodynamic therapy with polymer-bound anticancer drugs is explained. Research and clinical applications as well as directions for the future development of macromolecular therapeutics are discussed.
ISSN:0168-3659
1873-4995
DOI:10.1016/S0168-3659(01)00330-3