Glomerular Hyperfiltration, High Renin, and Low- Extracellular Volume in High Blood Pressure

Abnormal renovascular resistance and glomerular filtration rate are characteristic of established hypertension and may also be involved in its pathogenesis. To determine renal and body fluid correlates of the predisposition to high blood pressure, we examined 100 healthy young adults with high or lo...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-04, Vol.35 (4), p.952-957
Main Authors: Harrap, Stephen B, Cumming, Allan D, Davies, David L, Foy, Christopher J. W, Fraser, Robert, Kamitani, Atsushi, Connor, J Michael, Lever, Anthony F, Watt, Graham C. M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Female
Glomerular Filtration Rate
Humans
Hypertension - etiology
Hypertension - metabolism
Hypertension - physiopathology
Male
Medical sciences
Renin - metabolism
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Summary:Abnormal renovascular resistance and glomerular filtration rate are characteristic of established hypertension and may also be involved in its pathogenesis. To determine renal and body fluid correlates of the predisposition to high blood pressure, we examined 100 healthy young adults with high or low blood pressure. Within each group, half had parents with high blood pressures, and half had parents with low blood pressures. Renal function and hemodynamics, body fluid volumes, and relevant hormones and genotypes were measured. Subjects with high personal and parental blood pressures had the highest levels of glomerular filtration rate (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.35.4.952