Pharmacological Concentrations of Ascorbic Acid Are Required for the Beneficial Effect on Endothelial Vasomotor Function in Hypertension

Increased production of superoxide anion may contribute to impaired bioactivity of endothelium-derived nitric oxide in hypertension. Ascorbic acid is capable of scavenging superoxide anion; however, experimental studies have shown that high physiological concentrations (>1 mmol/L) of ascorbic aci...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-04, Vol.35 (4), p.936-941
Main Authors: Sherman, Debra L, Keaney, John F, Biegelsen, Elizabeth S, Duffy, Stephen J, Coffman, Jay D, Vita, Joseph A
Format: Article
Language:English
Subjects:
Adult
Ascorbic Acid - administration & dosage
Ascorbic Acid - therapeutic use
Biological and medical sciences
Cardiovascular system
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiopathology
Female
Forearm - blood supply
Free Radical Scavengers - administration & dosage
Free Radical Scavengers - therapeutic use
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Superoxides
Vascular wall
Vasodilation - drug effects
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Summary:Increased production of superoxide anion may contribute to impaired bioactivity of endothelium-derived nitric oxide in hypertension. Ascorbic acid is capable of scavenging superoxide anion; however, experimental studies have shown that high physiological concentrations (>1 mmol/L) of ascorbic acid are required to prevent superoxide-mediated vascular dysfunction. To seek kinetic evidence that superoxide anion contributes to endothelial vasomotor dysfunction in human hypertension, we examined the effects of 2.4 or 24 mg/min ascorbic acid intra-arterial infusions on forearm blood flow responses to methacholine or sodium nitroprusside in 30 patients with hypertension and 22 age-matched controls. Endothelium-dependent vasodilation to methacholine was significantly impaired in the hypertensive patients, with a response to the highest dose of methacholine (10 μg/min) of 12.3±6.7 compared with 16.1±5.8 mL · min · dL tissue in the controls (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.35.4.936