Endothelin-1 during and after cardiopulmonary bypass: Association to graft sensitivity and postoperative recovery

Objective: Our objectives are 2-fold: (1) to serially measure the release of endothelin and graft-conduit endothelin sensitivity during and after coronary artery bypass grafting and (2) to define potential relationships of changes in endothelin levels to perioperative parameters. Methods : Endotheli...

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Published in:	The Journal of thoracic and cardiovascular surgery 2001-08, Vol.122 (2), p.358-364
Main Authors:	Bond, Brian R., Dorman, B.Hugh, Clair, Mark J., Walker, C.Allyson, Pinosky, Mark L., Reeves, Scott T., Walton, Scott, Kratz, John M., Zellner, James L., Crumbley, A.Jackson, Multani, Marlina M., Spinale, Francis G.
Format:	Article
Language:	eng
Subjects:	Analysis of Variance Biological and medical sciences Cardiopulmonary Bypass Coronary Circulation Endothelin-1 - blood Female Humans Intensive Care Units Male Medical sciences Middle Aged Nitroglycerin - therapeutic use Respiration, Artificial Saphenous Vein - metabolism Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Thoracic Arteries - metabolism Vasodilator Agents - therapeutic use
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Summary:	Objective: Our objectives are 2-fold: (1) to serially measure the release of endothelin and graft-conduit endothelin sensitivity during and after coronary artery bypass grafting and (2) to define potential relationships of changes in endothelin levels to perioperative parameters. Methods : Endothelin plasma content was measured in patients (n = 105) undergoing bypass grafting from select vascular compartments before operations and at specific intervals up to 24 hours postoperatively. Endothelin sensitivity was determined in isolated internal thoracic artery segments. Results: Systemic arterial and pulmonary arterial endothelin levels were increased by approximately 50% immediately after bypass grafting and increased by another 85% during the first 24 hours postoperatively. Endothelin levels were highest in patients with prolonged ventilatory requirements and extended stays in the intensive care unit (10.2 ± 0.8 vs 13.2 ± 1.1 fmol/mL, P =.02, and 9.8 ± 0.7 vs 13.9 ± 1.2 fmol/mL, P =.01, respectively. Endothelin sensitivity of the internal thoracic artery was increased in patients requiring prolonged vasodilator support with nitroglycerin. Conclusions : Systemic and pulmonary arterial endothelin levels remained increased for at least 24 hours postoperatively. Prolonged pharmacologic management and increased intensive care unit stay were associated with increased systemic endothelin release and heightened graft-conduit sensitivity to endothelin. J Thorac Cardiovasc Surg 2001;122:358-64
ISSN:	0022-5223 1097-685X