Improvement in hypertension in patients with diabetes mellitus after kidney/pancreas transplantation

Hypertension persists in many patients with diabetes mellitus after kidney transplantation. However, the impact of control of diabetes as well as kidney failure on hypertension by combined kidney and pancreas transplantation has not been studied. Between March 1993 and August 1998, 111 patients with...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2001-07, Vol.104 (5), p.563-569
Main Authors: ELLIOTT, Michael D, KAPOOR, Ajoy, PARKER, Michele A, KAUFMAN, Dixon B, BONOW, Robert O, GHEORGHIADE, Mihai
Format: Article
Language:English
Subjects:
Adult
Antihypertensive Agents - therapeutic use
Biological and medical sciences
Blood Pressure - drug effects
Blood Pressure - physiology
Cyclosporine - therapeutic use
Diabetes Mellitus, Type 1 - physiopathology
Dose-Response Relationship, Drug
Female
Glycated Hemoglobin A - metabolism
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Immunosuppressive Agents - therapeutic use
Kidney Transplantation
Liver, biliary tract, pancreas, portal circulation, spleen
Male
Medical sciences
Middle Aged
Pancreas - physiopathology
Pancreas Transplantation
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Time Factors
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Summary:Hypertension persists in many patients with diabetes mellitus after kidney transplantation. However, the impact of control of diabetes as well as kidney failure on hypertension by combined kidney and pancreas transplantation has not been studied. Between March 1993 and August 1998, 111 patients with type 1 diabetes mellitus underwent successful pancreas transplantation (108 kidney/pancreas transplantation) and another 28 patients with type 1 diabetes mellitus underwent isolated kidney transplantation. Blood pressure measurements and all antihypertensive medications were determined for both groups before transplantation and at 1, 3, 6, and 12 months and at the most recent outpatient evaluation after transplantation. At baseline, the mean blood pressure was 151/88 and 151/83 mm Hg for the kidney/pancreas and isolated kidney transplant patients, respectively. The mean blood pressure decreased to 134/77 mm Hg 1 month after kidney/pancreas transplantation (P
ISSN:0009-7322
1524-4539
DOI:10.1161/hc3001.093434