Linkage and physical mapping of the porcine prepro-orexin gene

It is well established that the brain, and specifically the hypothalamus, is a major site where various central nervous system signals are integrated to affect the expression of complex hormonal and neuroendocrine functions, such as food intake and energy homeostasis. Orexin-A and B (also called pre...

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Bibliographic Details
Published in:Mammalian genome 2000-04, Vol.11 (4), p.342-343
Main Authors: Malek, M, Marklund, S, Dyer, C, Matteri, R, Rothschild, M
Format: Article
Language:English
Subjects:
Animals
Base Sequence
DNA
Exons
Genetic Linkage
Hybrid Cells
Intracellular Signaling Peptides and Proteins
Introns
Molecular Sequence Data
Neuropeptides
Orexin-A
Orexin-B
Orexins
Physical Chromosome Mapping - veterinary
Polymerase Chain Reaction
prepro-orexin
Protein Precursors - genetics
Swine - genetics
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Summary:It is well established that the brain, and specifically the hypothalamus, is a major site where various central nervous system signals are integrated to affect the expression of complex hormonal and neuroendocrine functions, such as food intake and energy homeostasis. Orexin-A and B (also called prepro-orexin), are hypothalamic peptides, encoded by a single mRNA transcript, which are derived from the same precursor. These peptides bind and activate two closely related orphan G protein-coupled receptors. Prepro-orexin has been proposed to have a physiological role in the regulation of food intake in the mouse, rat, pig, and human. Edwards et al. (1999) studied the effect of orexin-A and B on feed intake in the rat. Their data indicated that orexin-A consistently stimulated food intake, but orexin-B only occasionally stimulated food intake in the rat. Dyer et al. (1999) showed that cumulative feed intake increased by administration of orexin-B and total feed intake at 24 h was improved by 18% in orexin-treated pigs. Given the role of prepro-orexin, the present study was designed to characterize porcine prepro-orexin gene structure and chromosomal localization as a prelude to future candidate gene analysis for feed intake traits.
ISSN:0938-8990
1432-1777
DOI:10.1007/s003350010064