Liquid chromatographic determination of less polar ginsenosides in processed ginseng

Reversed-phase LC with an evaporative light scattering detector (ELSD) is used for the determination of less polar ginsenosides in processed ginseng. These ginsenosides include ginsenosides F 4, Rg 3, Rg 5, Rg 6, Rk 1, Rk 3, Rs 3, Rs 4, and Rs 5. The method used a C 18-bonded silica column with a CH...

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Bibliographic Details
Published in:Journal of Chromatography A 2001-07, Vol.921 (2), p.335-339
Main Authors: Kwon, Sung Won, Han, Sang Beom, Park, Il Ho, Kim, Jong Moon, Park, Man Ki, Park, Jeong Hill
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromatography, Liquid - methods
General pharmacology
Ginsenosides
Medical sciences
Panax - chemistry
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Saponins - analysis
Spectrometry, Mass, Electrospray Ionization
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Summary:Reversed-phase LC with an evaporative light scattering detector (ELSD) is used for the determination of less polar ginsenosides in processed ginseng. These ginsenosides include ginsenosides F 4, Rg 3, Rg 5, Rg 6, Rk 1, Rk 3, Rs 3, Rs 4, and Rs 5. The method used a C 18-bonded silica column with a CH 3CN/H 2O/CH 3COOH gradient elution. (20 R) and (20 S) epimers and geometric isomers at the C-20 position of ginsenosides, which are not generally separated by amino columns, were now clearly separated.
ISSN:0021-9673
DOI:10.1016/S0021-9673(01)00869-X