Serum müllerian-inhibiting substance levels during normal menstrual cycles

Objective: To measure serum levels of müllerian-inhibiting substance (MIS) during the normal menstrual cycle. Design: Serum was collected from women during ovulation and the mid-luteal and early follicular phases of the menstrual cycles. It was stored frozen at −80°C until assayed. Setting: Universi...

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Bibliographic Details
Published in:Fertility and sterility 2000-04, Vol.73 (4), p.859-861
Main Authors: Cook, Christine L, Siow, Yong, Taylor, Susan, Fallat, Mary E
Format: Article
Language:English
Subjects:
Adult
Anti-Mullerian Hormone
Biological and medical sciences
early follicular
Female
Fundamental and applied biological sciences. Psychology
Glycoproteins
Growth Inhibitors - blood
Hormone metabolism and regulation
Humans
Mammalian female genital system
Menstrual Cycle - physiology
mid-luteal
Müllerian-inhibiting substance
ovulation
Reference Values
Testicular Hormones - blood
Vertebrates: reproduction
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Summary:Objective: To measure serum levels of müllerian-inhibiting substance (MIS) during the normal menstrual cycle. Design: Serum was collected from women during ovulation and the mid-luteal and early follicular phases of the menstrual cycles. It was stored frozen at −80°C until assayed. Setting: University of Louisville Departments of Obstetrics and Gynecology and Surgery. Patient(s): Twenty healthy women 22–35 years of age with normal menstrual cycles. Intervention(s): Blood samples were collected on menstrual cycle day two or three and on the day of LH surge plus one and plus seven or eight. Main Outcome Measure(s): Serum MIS levels were measured by using an enzyme-linked immunosorbent assay. Result(s): Serum MIS levels ranged from a low of 1.4 ± 0.9 ng/mL (mean [±SD]) in the early follicular phase, peaked mid-cycle at 1.7 ± 1.1 ng/mL, and decreased to 1.4 ± 0.9 ng/mL in the mid-luteal phase of the normal menstrual cycle. Conclusion(s): Fluctuations in serum MIS levels during the menstrual cycle suggest that MIS may have a regulatory role in folliculogenesis.
ISSN:0015-0282
1556-5653
DOI:10.1016/S0015-0282(99)00639-1