Antifungal activity of magnolol and honokiol

Two neolignan compounds, magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl, 1) and honokiol (5,5'-diallyl-2,4'-dihydroxybiphenyl, 2), were isolated from the stem bark of Magnolia obovata and evaluated for antifungal activity against various human pathogenic fungi. Compound 1 and 2 sh...

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Bibliographic Details
Published in:Archives of pharmacal research 2000-02, Vol.23 (1), p.46-49
Main Authors: Bang, K H, Kim, Y K, Min, B S, Na, M K, Rhee, Y H, Lee, J P, Bae, K H
Format: Article
Language:English
Subjects:
Antifungal Agents - pharmacology
Biphenyl Compounds - pharmacology
Humans
Lignans
Microbial Sensitivity Tests
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Summary:Two neolignan compounds, magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl, 1) and honokiol (5,5'-diallyl-2,4'-dihydroxybiphenyl, 2), were isolated from the stem bark of Magnolia obovata and evaluated for antifungal activity against various human pathogenic fungi. Compound 1 and 2 showed significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 microg/ml. Therefore, compound 1 and 2 could be used as lead compounds for the development of novel antifungal agents.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02976465