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Serum leptin levels in pregnant women with type 1 diabetes mellitus
Background. Leptin is an important weight regulator and during pregnancy leptin is not only synthesized in adipose tissue but also in the placenta. Aim. To examine changes in serum leptin levels in women with type 1 diabetes mellitus during pregnancy and post delivery in relation to concomitant chan...
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| Published in: | Acta obstetricia et gynecologica Scandinavica 2001-07, Vol.80 (7), p.596-601 |
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| container_issue | 7 |
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| container_title | Acta obstetricia et gynecologica Scandinavica |
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| creator | Lauszus, Finn F. Schmitz, Ole Vestergaard, Henrik Klebe, Joachim G. Pedersen, Oluf |
| description | Background. Leptin is an important weight regulator and during pregnancy leptin is not only synthesized in adipose tissue but also in the placenta.
Aim. To examine changes in serum leptin levels in women with type 1 diabetes mellitus during pregnancy and post delivery in relation to concomitant changes in maternal body weight, birth weight, glycemic control, and blood pressure.
Methods. Non‐fasting serum leptin from 45 women with type 1 diabetes mellitus were studied consecutively throughout pregnancy and 3 months post partum.
Results. Serum leptin was positively associated with HbA1c in week 18, 22 and 30 (r=0.38, 0.41, and 0.54, respectively, p |
| doi_str_mv | 10.1034/j.1600-0412.2001.800702.x |
| format | article |
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Aim. To examine changes in serum leptin levels in women with type 1 diabetes mellitus during pregnancy and post delivery in relation to concomitant changes in maternal body weight, birth weight, glycemic control, and blood pressure.
Methods. Non‐fasting serum leptin from 45 women with type 1 diabetes mellitus were studied consecutively throughout pregnancy and 3 months post partum.
Results. Serum leptin was positively associated with HbA1c in week 18, 22 and 30 (r=0.38, 0.41, and 0.54, respectively, p<0.05, adjusted for body weight). Moreover, serum leptin correlated positively with maternal body weight and BMI (0.45<r<0.66, p<0.05). Serum leptin was significantly lower after delivery than during pregnancy where the levels showed no change from gestational week 14 to week 38. In obese women (BMI >25 kg/m2), the changes during pregnancy and the level of serum leptin were significantly greater compared to lean women (p<0.05). The women with low ambulatory blood pressure (lower tertile, mean arterial blood pressure <83.4 mmHg) showed the lowest level of serum leptin throughout pregnancy and it changed significantly differently from the women with higher blood pressure (p<0.05).
Conclusion. Changes in serum leptin levels of pregnant women with type 1 diabetes mellitus were associated with parallel changes in maternal body weight and glycemic control. Women with low blood pressure had the lowest serum leptin levels throughout pregnancy.]]></description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.1034/j.1600-0412.2001.800702.x</identifier><identifier>PMID: 11437715</identifier><identifier>CODEN: AOGSAE</identifier><language>eng</language><publisher>Copenhagen: Munksgaard International Publishers</publisher><subject>Adult ; Biological and medical sciences ; birth weight ; Birth Weight - physiology ; Blood Glucose - analysis ; blood pressure ; Blood Pressure - physiology ; Body Mass Index ; Body Weight - physiology ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Glycated Hemoglobin A - metabolism ; glycosylated hemoglobin (HbA1c) ; Humans ; Insulin - administration & dosage ; Leptin - blood ; maternal weight ; Medical sciences ; Pregnancy ; Pregnancy in Diabetics - blood ; Pregnancy in Diabetics - physiopathology ; serum leptin ; type 1 diabetes mellitus</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 2001-07, Vol.80 (7), p.596-601</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4322-6bfdb4e355ce4d150ca5507bc0fab43b33d9bf1d958a0afe2fc3e838338e1fdf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1600-0412.2001.800702.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1600-0412.2001.800702.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1066640$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11437715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lauszus, Finn F.</creatorcontrib><creatorcontrib>Schmitz, Ole</creatorcontrib><creatorcontrib>Vestergaard, Henrik</creatorcontrib><creatorcontrib>Klebe, Joachim G.</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><title>Serum leptin levels in pregnant women with type 1 diabetes mellitus</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand</addtitle><description><![CDATA[Background. Leptin is an important weight regulator and during pregnancy leptin is not only synthesized in adipose tissue but also in the placenta.
Aim. To examine changes in serum leptin levels in women with type 1 diabetes mellitus during pregnancy and post delivery in relation to concomitant changes in maternal body weight, birth weight, glycemic control, and blood pressure.
Methods. Non‐fasting serum leptin from 45 women with type 1 diabetes mellitus were studied consecutively throughout pregnancy and 3 months post partum.
Results. Serum leptin was positively associated with HbA1c in week 18, 22 and 30 (r=0.38, 0.41, and 0.54, respectively, p<0.05, adjusted for body weight). Moreover, serum leptin correlated positively with maternal body weight and BMI (0.45<r<0.66, p<0.05). Serum leptin was significantly lower after delivery than during pregnancy where the levels showed no change from gestational week 14 to week 38. In obese women (BMI >25 kg/m2), the changes during pregnancy and the level of serum leptin were significantly greater compared to lean women (p<0.05). The women with low ambulatory blood pressure (lower tertile, mean arterial blood pressure <83.4 mmHg) showed the lowest level of serum leptin throughout pregnancy and it changed significantly differently from the women with higher blood pressure (p<0.05).
Conclusion. Changes in serum leptin levels of pregnant women with type 1 diabetes mellitus were associated with parallel changes in maternal body weight and glycemic control. Women with low blood pressure had the lowest serum leptin levels throughout pregnancy.]]></description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>birth weight</subject><subject>Birth Weight - physiology</subject><subject>Blood Glucose - analysis</subject><subject>blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Body Mass Index</subject><subject>Body Weight - physiology</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>glycosylated hemoglobin (HbA1c)</subject><subject>Humans</subject><subject>Insulin - administration & dosage</subject><subject>Leptin - blood</subject><subject>maternal weight</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - blood</subject><subject>Pregnancy in Diabetics - physiopathology</subject><subject>serum leptin</subject><subject>type 1 diabetes mellitus</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqNkE1v1DAQhi0EotvCX0BBQtwSxvFHkhvVQhfUqj2wVY-W44zBS5JN7YTd_fd4lVXh2JPHmmfeGT2EvKeQUWD80yajEiAFTvMsB6BZCVBAnu1fkMVT5yVZQOylkvHqjJyHsIm_vODla3JGKWdFQcWCLH-gn7qkxWF0fXz-YBuSWA0ef_a6H5PdtsM-2bnxVzIeBkxo0jhd44gh6bBt3TiFN-SV1W3At6f3gtxffV0vv6U3d6vvy8ub1HCW56msbVNzZEIY5A0VYLQQUNQGrK45qxlrqtrSphKlBm0xt4ZhyUrGSqS2seyCfJxzB799nDCMqnPBxCN0j9spqAKqgjOgEaxm0PhtCB6tGrzrtD8oCupoUG3U0ZM6elJHg2o2qPZx9t1pyVR32PybPCmLwIcToIPRrfW6Ny78t0FKySFin2ds51o8PP8AdXm3musYkc4RLoy4f4rQ_reSBSuEerhdqfzLWq6vr6US7C86OZuS</recordid><startdate>200107</startdate><enddate>200107</enddate><creator>Lauszus, Finn F.</creator><creator>Schmitz, Ole</creator><creator>Vestergaard, Henrik</creator><creator>Klebe, Joachim G.</creator><creator>Pedersen, Oluf</creator><general>Munksgaard International Publishers</general><general>Taylor & Francis</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200107</creationdate><title>Serum leptin levels in pregnant women with type 1 diabetes mellitus</title><author>Lauszus, Finn F. ; Schmitz, Ole ; Vestergaard, Henrik ; Klebe, Joachim G. ; Pedersen, Oluf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4322-6bfdb4e355ce4d150ca5507bc0fab43b33d9bf1d958a0afe2fc3e838338e1fdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>birth weight</topic><topic>Birth Weight - physiology</topic><topic>Blood Glucose - analysis</topic><topic>blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Body Mass Index</topic><topic>Body Weight - physiology</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>glycosylated hemoglobin (HbA1c)</topic><topic>Humans</topic><topic>Insulin - administration & dosage</topic><topic>Leptin - blood</topic><topic>maternal weight</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - blood</topic><topic>Pregnancy in Diabetics - physiopathology</topic><topic>serum leptin</topic><topic>type 1 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lauszus, Finn F.</creatorcontrib><creatorcontrib>Schmitz, Ole</creatorcontrib><creatorcontrib>Vestergaard, Henrik</creatorcontrib><creatorcontrib>Klebe, Joachim G.</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lauszus, Finn F.</au><au>Schmitz, Ole</au><au>Vestergaard, Henrik</au><au>Klebe, Joachim G.</au><au>Pedersen, Oluf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum leptin levels in pregnant women with type 1 diabetes mellitus</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand</addtitle><date>2001-07</date><risdate>2001</risdate><volume>80</volume><issue>7</issue><spage>596</spage><epage>601</epage><pages>596-601</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><coden>AOGSAE</coden><notes>istex:18D21965EF67270203F907801A850A86C63EF6B1</notes><notes>ArticleID:AOG800702</notes><notes>ark:/67375/WNG-2DT6TKK6-5</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract><![CDATA[Background. Leptin is an important weight regulator and during pregnancy leptin is not only synthesized in adipose tissue but also in the placenta.
Aim. To examine changes in serum leptin levels in women with type 1 diabetes mellitus during pregnancy and post delivery in relation to concomitant changes in maternal body weight, birth weight, glycemic control, and blood pressure.
Methods. Non‐fasting serum leptin from 45 women with type 1 diabetes mellitus were studied consecutively throughout pregnancy and 3 months post partum.
Results. Serum leptin was positively associated with HbA1c in week 18, 22 and 30 (r=0.38, 0.41, and 0.54, respectively, p<0.05, adjusted for body weight). Moreover, serum leptin correlated positively with maternal body weight and BMI (0.45<r<0.66, p<0.05). Serum leptin was significantly lower after delivery than during pregnancy where the levels showed no change from gestational week 14 to week 38. In obese women (BMI >25 kg/m2), the changes during pregnancy and the level of serum leptin were significantly greater compared to lean women (p<0.05). The women with low ambulatory blood pressure (lower tertile, mean arterial blood pressure <83.4 mmHg) showed the lowest level of serum leptin throughout pregnancy and it changed significantly differently from the women with higher blood pressure (p<0.05).
Conclusion. Changes in serum leptin levels of pregnant women with type 1 diabetes mellitus were associated with parallel changes in maternal body weight and glycemic control. Women with low blood pressure had the lowest serum leptin levels throughout pregnancy.]]></abstract><cop>Copenhagen</cop><pub>Munksgaard International Publishers</pub><pmid>11437715</pmid><doi>10.1034/j.1600-0412.2001.800702.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta obstetricia et gynecologica Scandinavica, 2001-07, Vol.80 (7), p.596-601 |
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| source | Wiley |
| subjects | Adult Biological and medical sciences birth weight Birth Weight - physiology Blood Glucose - analysis blood pressure Blood Pressure - physiology Body Mass Index Body Weight - physiology Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glycated Hemoglobin A - metabolism glycosylated hemoglobin (HbA1c) Humans Insulin - administration & dosage Leptin - blood maternal weight Medical sciences Pregnancy Pregnancy in Diabetics - blood Pregnancy in Diabetics - physiopathology serum leptin type 1 diabetes mellitus |
| title | Serum leptin levels in pregnant women with type 1 diabetes mellitus |
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