Serum leptin levels in pregnant women with type 1 diabetes mellitus

Background. Leptin is an important weight regulator and during pregnancy leptin is not only synthesized in adipose tissue but also in the placenta. Aim. To examine changes in serum leptin levels in women with type 1 diabetes mellitus during pregnancy and post delivery in relation to concomitant chan...

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Bibliographic Details
Published in:Acta obstetricia et gynecologica Scandinavica 2001-07, Vol.80 (7), p.596-601
Main Authors: Lauszus, Finn F., Schmitz, Ole, Vestergaard, Henrik, Klebe, Joachim G., Pedersen, Oluf
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
birth weight
Birth Weight - physiology
Blood Glucose - analysis
blood pressure
Blood Pressure - physiology
Body Mass Index
Body Weight - physiology
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Glycated Hemoglobin A - metabolism
glycosylated hemoglobin (HbA1c)
Humans
Insulin - administration & dosage
Leptin - blood
maternal weight
Medical sciences
Pregnancy
Pregnancy in Diabetics - blood
Pregnancy in Diabetics - physiopathology
serum leptin
type 1 diabetes mellitus
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Summary:Background. Leptin is an important weight regulator and during pregnancy leptin is not only synthesized in adipose tissue but also in the placenta. Aim. To examine changes in serum leptin levels in women with type 1 diabetes mellitus during pregnancy and post delivery in relation to concomitant changes in maternal body weight, birth weight, glycemic control, and blood pressure. Methods. Non‐fasting serum leptin from 45 women with type 1 diabetes mellitus were studied consecutively throughout pregnancy and 3 months post partum. Results. Serum leptin was positively associated with HbA1c in week 18, 22 and 30 (r=0.38, 0.41, and 0.54, respectively, p
ISSN:0001-6349
1600-0412
DOI:10.1034/j.1600-0412.2001.800702.x